Matthew M. Crum

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We evaluate the rePLay microarchitecture as a means for reducing application execution time by facilitating dynamic optimization. The framework contains a programmable optimization engine coupled with a hardware-based recovery mechanism. The optimization engine enables the dynamic optimizer to run concurrently with program execution. The recovery mechanism(More)
For a variety of reasons, branch-less regions of instructions are desirable for high-performance execution. In this paper, we propose a means for increasing the dynamic length of branch-less regions of instructions for the purposes of dynamic program optimization. We call these atomic regions frames and we construct them by replacing original branch(More)
Small conductance Ca2+-activated K+ channels (SK channels) are composed of the pore-forming alpha subunit and calmodulin (CaM). CaM binds to a region of the alpha subunit called the CaM binding domain (CaMBD), located intracellular and immediately C-terminal to the inner helix gate, in either the presence or absence of Ca2+. SK gating occurs when Ca2+ binds(More)
We examined the changes that occur in the adenosine receptor system during diabetes mellitus. Experimental diabetes mellitus was induced in male Lewis rats with streptozocin (65 mg/kg), and A(1) adenosine receptor binding was characterized with [(125)I]N (6)-2-(4-aminophenyl) ethyladenosine. In adipocytes, high-affinity A(1) adenosine receptor binding(More)
Hydrophobic drugs present a challenge due to: (i) adhesion and agglomeration; hence the choice of the suitable processing technique to have the drugs into orally administered dosage forms is critical. (ii) Poor dissolution and poor aqueous solubility; hence poor bioavailability. A novel method which is in situ lyophilisation directly in hard gelatin capsule(More)
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