Matthew Lovett-Barron

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Transforming synaptic input into action potential output is a fundamental function of neurons. The pattern of action potential output from principal cells of the mammalian hippocampus encodes spatial and nonspatial information, but the cellular and circuit mechanisms by which neurons transform their synaptic input into a given output are unknown. Using a(More)
Fear memories guide adaptive behavior in contexts associated with aversive events. The hippocampus forms a neural representation of the context that predicts aversive events. Representations of context incorporate multisensory features of the environment, but must somehow exclude sensory features of the aversive event itself. We investigated this(More)
Adult-born granule cells (abGCs) have been implicated in cognition and mood; however, it remains unknown how these cells behave in vivo. Here, we have used two-photon calcium imaging to monitor the activity of young abGCs in awake behaving mice. We find that young adult-born neurons fire at a higher rate in vivo but paradoxically exhibit less spatial tuning(More)
CA1 pyramidal cells (PCs) are not homogeneous but rather can be grouped by molecular, morphological, and functional properties. However, less is known about synaptic sources differentiating PCs. Using paired recordings in vitro, two-photon Ca(2+) imaging in vivo, and computational modeling, we found that parvalbumin-expressing basket cells (PVBCs) evoked(More)
Hippocampal interneurons receive GABAergic input from the medial septum. Using two-photon Ca2+ imaging of axonal boutons in hippocampal CA1 of behaving mice, we found that populations of septo-hippocampal GABAergic boutons were activated during locomotion and salient sensory events; sensory responses scaled with stimulus intensity and were abolished by(More)
Impulse control suppresses actions that are inappropriate in one context, but may be beneficial in others. The medial prefrontal cortex (mPFC) mediates this process by providing a top-down signal to inhibit competing responses, although the mechanism by which the mPFC acquires this ability is unknown. To that end, we examined synaptic changes in the mPFC(More)
The majority of cellular diversity in the hippocampus and neocortex derives from a relatively small population of local inhibitory interneurons. Recent technological advances have facilitated the recording and manipulation of defined inhibitory cell classes in awake rodents, revealing new and surprising roles for these cells in local circuit function and(More)
How do fluctuations in the level of generalized arousal of the brain affect the performance of specific motivated behaviors, such as sexual behaviors that depend on sexual arousal? A great deal of previous work has provided us with two important starting points in answering this question: (i) that histamine (HA) serves generalized CNS arousal and (ii) that(More)
13. Blinzinger, K. & Kreutzberg, G.W. Z. Zellforsch. 85, 145–157 (1968). 14. Schafer, D.P. et al. Neuron 74, 691–705 (2012). 15. Sierra, A. et al. Cell Stem Cell 7, 483–495 (2010). 10. Ransohoff, R.M. & Cardona, A.E. Nature 468, 253–262 (2010). 11. Varvel, N.H. et al. Proc. Natl. Acad. Sci. USA 109, 18150–18155 (2012). 12. Kettenmann, H., Kirchhoff, F. &(More)
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