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BACKGROUND The pagN gene of Salmonella enterica serovar Typhimurium is a PhoP-regulated gene that is up-regulated during growth within macrophages and in vivo in murine models of infection. The PagN protein displays similarity to the Hek and Tia invasins/adhesins of Escherichia coli. Thus far no function has been ascribed to the PagN protein. RESULTS Here(More)
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART ®) bispecific molecule against P-cadherin and CD3 that demonstrates antibody-like properties. Using phage display, we identified(More)
Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA Scientific and Technical Information (STI) Program Office plays a key part in helping NASA maintain this important role. The NASA STI Program Office is operated by Langley Research Center, the lead center for NASA's scientific and technical information.(More)
Three methods for attribute reduction in conjunction with Neural Networks, Naive Bayes, and k-Nearest Neighbor clas-sifiers are investigated here when classifying a particularly challenging data set. The difficulty encountered with this data set is mainly due to the high dimensionality and to some in-balance between classes. As a result of this research, a(More)
  • Randall H. Caton, Christopher Newport, Thomas E. Pinelli, Ellen B. Holmes, Matthew A. Lambert
  • 2005
Since its founding, NASA has been dedicated to the advancement of aeronautics and space science. The NASA Scientific and Technical Information (STI) Program Office plays a key part in helping NASA maintain this important role. The NASA STI Program Office is operated by Langley Research Center, the lead center for NASA's scientific and technical information.(More)
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