Matthew Lambert

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The integrin αIIbβ3 on resting platelets can bind to immobilised fibrinogen resulting in platelet spreading and activation but requires activation to bind to soluble fibrinogen. αIIbβ3 is known to interact with the general integrin-recognition motif RGD (arginine-glycine-aspartate) as well as the fibrinogen-specific γ-chain dodecapeptide; however, it is not(More)
Left ventricular (LV) remodelling following myocardial infarction (MI) is associated with increased morbidity and mortality. Previous data suggest that angiotensin II (Ang II) plays a central role in the molecular events contributing to LV remodelling. We explored the effects of angiotensin-converting-enzyme (ACE) inhibition versus Ang II (AT(1)) receptor(More)
Three methods for attribute reduction in conjunction with Neural Networks, Naive Bayes, and k-Nearest Neighbor classifiers are investigated here when classifying a particularly challenging data set. The difficulty encountered with this data set is mainly due to the high dimensionality and to some inbalance between classes. As a result of this research, a(More)