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Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape.
Inhibitory receptors on immune cells are pivotal regulators of immune escape in cancer. Among these inhibitory receptors, CTLA-4 (targeted clinically by ipilimumab) serves as a dominant off-switchExpand
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Stability and function of regulatory T cells is maintained by a neuropilin-1–semaphorin-4a axis
Regulatory T cells (Treg cells) have a crucial role in the immune system by preventing autoimmunity, limiting immunopathology, and maintaining immune homeostasis. However, they also represent a majorExpand
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Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Regulatory T (Treg) cells, driven by the Foxp3 transcription factor, are responsible for limiting autoimmunity and chronic inflammation. We showed that a well-characterized Foxp3(gfp) reporter mouse,Expand
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Thymocyte Development in Early Growth Response Gene 1-Deficient Mice1
Early growth response gene 1 (Egr1) codes for a transcriptional regulator that contains a zinc-finger DNA binding domain. Egr1 expression is induced by a variety of extracellular stimuli includingExpand
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Distinct T cell receptor signaling pathways drive proliferation and cytokine production in T cells
The physiological basis and mechanistic requirements for a large number of functional immunoreceptor tyrosine-based activation motifs (ITAMs; high ITAM multiplicity) in the complex of the T cellExpand
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Critical Role for the Microbiota in CX3CR1+ Intestinal Mononuclear Phagocyte Regulation of Intestinal T Cell Responses
Summary The intestinal barrier is vulnerable to damage by microbiota‐induced inflammation that is normally restrained through mechanisms promoting homeostasis. Such disruptions contribute toExpand
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Development of thymically derived natural regulatory T cells
Natural regulatory T cells (nTregs) are defined by their inherent ability to establish and maintain peripheral self‐tolerance. In recent years, the development of nTregs has come under closeExpand
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MAP kinase phosphatase activity sets the threshold for thymocyte positive selection
Phosphorylation of MAP kinases is important for proper translation of T cell antigen receptor (TCR) signals into thymocyte cell fates, but the role of MAP kinase phosphatase (MKP) activity inExpand
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Membrane Association of the CD3ε Signaling Domain Is Required for Optimal T Cell Development and Function
The TCR:CD3 complex transduces signals that are critical for optimal T cell development and adaptive immunity. In resting T cells, the CD3ε cytoplasmic tail associates with the plasma membrane via aExpand
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T‐cell receptor retrogenic mice: a rapid, flexible alternative to T‐cell receptor transgenic mice
The T‐cell receptor (TCR) is unique in its complexity. It determines not only positive (life) and negative (death) selection in the thymus, but also mediates proliferation, anergy, differentiation,Expand
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