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Genomics has reached the stage at which the amount of DNA sequence information in existing databases is quite large. Synthetic biology is now using these databases to catalog sequences according to their functionality thus creating a system of standard biological parts. Flexible tools are needed which both permit access and modification to that data and(More)
PREMISE OF THE STUDY Using sequence data generated via target enrichment for phylogenetics requires reassembly of high-throughput sequence reads into loci, presenting a number of bioinformatics challenges. We developed HybPiper as a user-friendly platform for assembly of gene regions, extraction of exon and intron sequences, and identification of paralogous(More)
The goal of this covert channel is to prove the feasibility of using encrypted HTTPS traffic to carry a covert channel. The encryption key is not needed because the original HTTPS payload is not decrypted. The covert message will be appended to the HTTPS data field. The receiver will extract the covert channel and restore the original HTTPS traffic for(More)
PREMISE OF THE STUDY We used moderately low-coverage (17×) whole-genome sequencing of Artocarpus camansi (Moraceae) to develop genomic resources for Artocarpus and Moraceae. METHODS AND RESULTS A de novo assembly of Illumina short reads (251,378,536 pairs, 2 × 100 bp) accounted for 93% of the predicted genome size. Predicted coding regions were used in a(More)
Utilizing the co-transfection assay as a guide to determining structure activity relationships, we have been pursuing the discovery of non-steroidal hPR modulators. Small molecule, non-steroidal lead structures have been identified. Optimization of these structures has yielded more potent hPR modulators. Improved cross-reactivity profiles with other(More)
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