Matthew J Turnbull

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The site of action of the antispastic drug baclofen has long been considered to reside in the spinal cord although supraspinal effects have also been reported. This beta-chlorophenyl derivative of the neurotransmitter gamma-aminobutyric acid (GABA) depresses both monosynaptic and polysynaptic transmission in the cord possibly through a decrease in(More)
Receptors for GABA in the mammalian brain are not homogeneous. A clear separation exists between receptors which recognize the antagonist bicuculline and a population which does not. These two classes have been designated GABAA and GABAB sites respectively. Within the GABAA category there may also be many subtypes which exhibit subtle pharmacological(More)
The action of gamma-aminobutyric acid (GABA) and related compounds on rat isolated atria and mouse and guinea pig isolated vas deferens has been studied. GABA depressed the evoked but not basal release of [3H]noradrenaline from atria (IC50 4 micro M) and reduced the twitch responses of the vas deferens (IC50 3 micro M) in a dose-dependent manner. These(More)
Neurones in the substantia nigra were found to be sensitive to iontophoretically applied substance P, substance P 1-9 methyl ester and substance P 1-9 amide. Substance P 1-2, 4-9 and 5-9 methyl esters, thyrotropin releasing hormone (TRH), Pyroglutamyl-histidyl-2 methyl prolineamide (methyl TRH), Pyroglutamyl-histidyl-2 methyl prolineamide (methyl TRH),(More)
1. L-DOPA was administered to rats by twice daily intraperitoneal injection for a period of eleven days. The daily dose was gradually increased from 250 mg/kg to 1 g/kg. The animals were killed 12 h after the last injection and tissue catechol-O-methyl transferase, DOPA-decarboxylase and monoamine oxidase activity determined.2. Catechol-O-methyl transferase(More)
3 experimental approaches to the quantitation of acute barbiturate tolerance have been compared in the rat. There was no difference between the brain hexobarbitone or barbitone concentration found at the time of loss of righting reflex compared with the concentration found on return of the righting reflex following the period of anaesthesia produced by a(More)