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Pulmonary drug delivery is the focus of much research and development because of its great potential to produce maximum therapeutic benefit. Among the available options the dry powder inhaler (DPI) is the preferred device for the treatment of an increasingly diverse number of diseases. However, as drug delivery from a DPI involves a complicated set of(More)
Rubella (German measles) is a common viral infection in children and adults. It is usually a mild disease with few complications and resultant sequelae. Maternal infection with rubella, however, can cause severe congenital defects, known as congenital rubella syndrome. Although the incidence of rubella has declined, about 15 percent of women of childbearing(More)
Phenylketonuria (PKU) is an autosomal recessive inborn error of metabolism (OMIM 261600). Treatment with a low-phenylalanine diet following early ascertainment by newborn screening prevents impaired cognitive development, the major disease phenotype in PKU. The overall birth prevalence of PKU in European, Chinese and Korean populations is approximately(More)
Malignant otitis externa is a destructive inflammatory process of the petrous temporal bone which if untreated leads to osteomyelitis of the skull base and can be fatal. It is more common in immunocompromised and elderly insulin-dependant diabetic patients and is caused by infection with Pseudomonas species. Despite a range of laboratory and radiological(More)
Respiratory failure is a well-documented potential presentation of inherited isolated remethylation disorders (IRDs). It appears to be a combination of both central and peripheral neuropathy and has previously often been considered to herald an irreversible neurological decline. We present three patients, one with methionine synthase (cblG) and two with(More)
Gasification of coal or biomass with in-situ CO 2 capture is an emerging technology aiming to address the problem of climate change. Development of a CO 2 sorbent with desirable properties and understanding the behavior of such a material in carbonation/calcination reactions is an important part of developing the technology. In this paper, we report(More)
The efficient management of day surgery facilities benefits both patients and health administrators. Patients can benefit through minimisation of hospital stay while day surgery has the potential to increase elective surgery throughput and to reduce waiting times. This paper explores whether routinely collected morbidity data from Queensland public(More)