Matthew Hancock

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We describe a method for high-throughput analysis of protein-binding sites in DNA using 96-well plates and capillary electrophoresis. The genomic DNA or plasmid DNA to be analyzed is amplified using fluorescent primers, incubated with an appropriate nuclear extract and treated with DNase I. Separation of the DNase I-generated fragments and co-analysis of(More)
Flavin-containing monooxygenases (FMOs) of mammals are thought to be involved exclusively in the metabolism of foreign chemicals. Here, we report the unexpected finding that mice lacking Fmos 1, 2 and 4 exhibit a lean phenotype and, despite similar food intake, weigh less and store less triglyceride in white adipose tissue (WAT) than wild-type mice. This is(More)
The paper presents a global chassis control (GCC) optimization approach using a gradient-based optimal control algorithm. The goal is to find optimal actions of various actuators such as active steering and active differential, which ensure satisfying the optimization criterion (e.g. trajectory following error minimization) subject to different equality and(More)
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