Matthew H. Perkins

Elizabeth C Cropper3
Michael J Siniscalchi2
Yi-Qing Qian1
3Elizabeth C Cropper
2Michael J Siniscalchi
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MOTIVATION Genome-wide mRNA profiling provides a snapshot of the global state of cells under different conditions. However, mRNA levels do not provide direct understanding of upstream regulatory mechanisms. Here, we present a new approach called Expression2Kinases (X2K) to identify upstream regulators likely responsible for observed patterns in genome-wide(More)
Motor activity is often initiated by a population of command-like interneurons. Command-like interneurons that reliably drive programs have received the most attention, so little is known about how less reliable command-like interneurons may contribute to program generation. We study two electrically coupled interneurons, cerebral-buccal interneuron-2(More)
Complex behaviors often require coordinated movements of dissimilar motor structures. The underlying neural mechanisms are poorly understood. We investigated cycle-by-cycle coordination of two dissimilar feeding structures in Aplysia californica: the external lips and the internal radula. During feeding, the lips open while the radula protracts. Lip and(More)
It is becoming apparent that the activity of many neural networks is shaped by effects of endogenous neuromodulators. Modulators exert second messenger-mediated actions that persist. We consider how this may impact network function and its potential role in the induction of repetition priming (increased performance when behavior is repeated). When effects(More)
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