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With the continual improvement in spatial resolution of Nuclear Medicine (NM) scanners, it has become increasingly important to accurately compensate for patient motion during image acquisition. Respiratory motion produced by normal lung ventilation is a major source of artefacts in NM emission imaging that can affect large parts of the abdominal thoracic(More)
We report what is to our knowledge the first femtosecond pulse generation at 1.3 micro m in a Pr 3(+)-doped fluoride fiber laser. After optimization of the cavity length and dispersion, the laser generated pulses as short as 620 fs. We also describe self-stabilization and self-organization of the output pulse train at repetition rates from the fundamental(More)
The limitations of traditional targeted radionuclide therapy (TRT) dosimetry can be overcome by using voxel-based techniques. All dosimetry techniques are reliant on a sequence of quantitative emission and transmission data. The use of (131)I, for example, with NaI or mIBG, presents additional quantification challenges beyond those encountered in low-energy(More)
Motion correction of the abdominal-thoracic region is one of the main research challenges in tomographic nuclear medicine imaging. We address this issue with a flexible data-driven method of motion correction. This uses marker-less stereo tracking of the anterior abdominal-chest surface and a 'virtual dissection'-based registration approach, combined within(More)
One of the current major challenges in clinical imaging is modeling and prediction of respiratory motion, for example, in nuclear medicine or external-beam radio therapy. This paper presents preliminary work in developing a method for modeling and predicting the temporal behavior of the anterior surface position during respiration. This is achieved by(More)
In this paper a novel, automated CT marker segmentation technique for image registration is described. The technique, which is based on analysing each CT slice contour individually, treats the cross sections of the external markers as protrusions of the slice contour. Knowledge-based criteria, using the shape and dimensions of the markers, are defined to(More)
Primary ciliary dyskinesia (PCD) is a genetic condition affecting one in 10 000–40 000 people from birth [1]; cilia fail to beat, and the airway clearance of mucus and debris is severely impaired. If untreated, this results in progressive lung infection leading to bronchiectasis and ultimately respiratory failure. Additionally, delayed diagnosis has(More)
In nuclear medicine, there is a significant research focus in developing a new approach in monitoring, tracking and compensating respiratory motion during image acquisition. We address this by attempting to model the respiratory cycle pattern and finding a method that describes the configuration of the anterior surface which then correlates with the(More)