Matthew Gutowski

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The effects of low level lead exposure on synaptic plasticity in hippocampal regions CA1 and CA3 were determined in adult rats in vitro. In the CA3 region the NMDA (N-methyl-D-aspartate)-independent mossy fiber-CA3 synapse potentiation was not influenced by chronic pre- and postnatal lead exposure, while in the same rats, in the CA1 region the(More)
The objective of the present study was, by using the Mongolian gerbil (Meriones unguiculatus) as an animal model, to provide data on the growth dynamics of central auditory and visual nuclei and to relate the growth of these structures to the growth of the entire brain. So far, no such systematic study has been performed in any mammalian species. The(More)
We examined the amount of long-term potentiation (LTP) in slices from the visual cortex and hippocampus of pre- and postnatally lead-exposed rats and controls at postnatal days (PND) 12-20. A dietary lead intake of 750 ppm by the dams resulted in a mean blood lead concentration in the suckling offspring of about 17' micrograms/dl. While high-frequency(More)
The object of this study was to compare the postnatal development of mossy fiber potentiation (MFP) and paired-pulse facilitation in the CA3 region of control and led-exposed rats. The postnatal development of MFP was not influenced by the chronic pre- and postnatal lead exposure nor did we find a statistically significant impairment of MFP in region CA3(More)
This report summarizes the research efforts of using finite element modeling and simulations to evaluate the performance of generic low-tension cable median barriers (CMBs) on four-lane and six-lane freeways with a 46-foot median, horizontal curvature, and 6:1 and 4:1 median slopes. A literature review is included on the performance evaluation of CMBs and(More)
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