Matthew Goode

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PURPOSE To update the American Society of Clinical Oncology/American Society of Hematology (ASCO/ASH) recommendations for the use of epoetin. The guideline was expanded to address use of darbepoetin and thromboembolic risk associated with these agents. METHOD An Update Committee ("Committee") reviewed and analyzed data published since 2002 through July(More)
PURPOSE To update American Society of Clinical Oncology/American Society of Hematology recommendations for use of erythropoiesis-stimulating agents (ESAs) in patients with cancer. METHODS An Update Committee reviewed data published between January 2007 and January 2010. MEDLINE and the Cochrane Library were searched. RESULTS The literature search(More)
Anemia resulting from cancer or its treatment is an important clinical problem increasingly treated with the recombinant hematopoietic growth factor erythropoietin. To address uncertainties regarding indications and efficacy, the American Society of Clinical Oncology and the American Society of Hematology developed an evidence-based clinical practice(More)
DNA Surveillance is a Web-based application that assists in the identification of the species and population of unknown specimens by aligning user-submitted DNA sequences with a validated and curated data set of reference sequences. Phylogenetic analyses are performed and results are returned in tree and table format summarizing the evolutionary distances(More)
BACKGROUND & AIMS Although viral quasi-species evolution may be related to pathogenesis of disease, little is known about this in hepatitis B virus (HBV); consequently, we aimed to evaluate the evolution of HBV quasi-species in patients with well-characterized clinical phenotypes of chronic hepatitis B. METHODS Four cohorts of well-defined clinical(More)
Free-ranging prairie rattlesnakes (Crotalus viridis viridis) exhibit lengthy vernal migrations upon emergence from winter hibernation. A series of laboratory experiments was designed to test hypotheses regarding the function and causation of vernal movements. Rattlesnakes obtained from Wyoming and Colorado populations were used. First, we hypothesized that(More)
Models of nucleotide or amino acid sequence evolution that implement homogeneous and stationary Markov processes of substitutions are mathematically convenient but are unlikely to represent the true complexity of evolution. With the large amounts of data that next generation sequencing promises, appropriate models of evolution are important, particularly(More)
The estimation of evolutionary rates from serially sampled sequences has recently been the focus of several studies. In this paper, we extend these analyzes to allow the estimation of a joint rate of substitution, omega, from several evolving populations from which serial samples are drawn. In the case of viruses evolving in different hosts, therapy may(More)