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Models of nucleotide or amino acid sequence evolution that implement homogeneous and stationary Markov processes of substitutions are mathematically convenient but are unlikely to represent the true complexity of evolution. With the large amounts of data that next generation sequencing promises, appropriate models of evolution are important, particularly(More)
PURPOSE To update the American Society of Clinical Oncology/American Society of Hematology (ASCO/ASH) recommendations for the use of epoetin. The guideline was expanded to address use of darbepoetin and thromboembolic risk associated with these agents. METHOD An Update Committee ("Committee") reviewed and analyzed data published since 2002 through July(More)
Free-ranging prairie rattlesnakes (Crotalus viridis viridis) exhibit lengthy vernal migrations upon emergence from winter hibernation. A series of laboratory experiments was designed to test hypotheses regarding the function and causation of vernal movements. Rattlesnakes obtained from Wyoming and Colorado populations were used. First, we hypothesized that(More)
Amphid sensilla, historically considered the primary chemosensory structures of nematodes, were found to be necessary for the detection of only one of the six chemical stimuli that were tested. Only the attraction to cAMP was eliminated by damaging the two lateral lips, which bear the amphid sensilla. The inner labial sensilla, one of which occurs on each(More)
The tethered-nematode technique was adapted for use with second-stage juveniles of Meloidogyne incognita. The data demonstrate that M. incognita exhibits the same patterns of behavior as adults of the free-living nematode, Caenorhabditis elegans. The principal differences are that M. incognita is slower and less regular in its behavior than C. elegans. The(More)
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