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The rapidly aging population desperately requires new therapies for Alzheimer's disease. Despite years of pharmaceutical research, limited clinical success has been realized, with several failed… (More)
BackgroundFamilial Alzheimer’s disease (FAD) is caused by mutations in the amyloid precursor protein (APP) or presenilin (PS). Most PS mutations, which account for the majority of FAD cases, lead to… (More)
The mammalian target of rapamycin (mTOR) is a central regulator of cell growth, metabolism, and angiogenesis and an emerging target in cancer research. High throughput screening (HTS) of our compound… (More)
Acidic mammalian chitinase (AMCase) is a member of the glycosyl hydrolase 18 family (EC 22.214.171.124) that has been implicated in the pathophysiology of allergic airway disease such as asthma. Small… (More)
Structure-generating programs provide rational methods to rapidly design novel scaffolds targeting the biologic receptor of choice. Recent research has demonstrated proteins equilibrate between… (More)
La presente invention concerne des composes ayant la formule (I) dans laquelle R1, R2, R3, R4, R5, et R6 sont definis dans le descriptif associe.
La presente invention concerne des composes, des compositions pharmaceutiques et des medicaments comprenant de tels composes, et l'utilisation de ces composes, de ces compositions et de ces… (More)
La presente invention concerne des analogues de pyrazolopyrimidine, des procedes de preparation d'analogues de pyrazolopyrimidine et des compositions comprenant un analogue de pyrazolopyrimidine et… (More)