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Once, in a story, I wrote that Indians are everywhere. Goddamn right. 1 —Simon J. Ortiz Tribal histories often begin long before there were humans walking on the earth. According to the creation story of the Anishinabeg, 2 for example, the Great Mystery, Kitche Manitou, created the world free from human habitation. 3 But disaster befell the world and it(More)
Enzymatic depletion of the nonessential amino acid l-Arginine (l-Arg) in patients with cancer by the administration of a pegylated form of the catabolic enzyme arginase I (peg-Arg I) has shown some promise as a therapeutic approach. However, l-Arg deprivation also suppresses T-cell responses in tumors. In this study, we sought to reconcile these(More)
BACKGROUND Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B(More)
INTRODUCTION TO THE RESTATEMENT " When the Eagle returns we will again be a great nation " – Jonas Shawandase, Grand Traverse Band Tribal Elder from 1930-1950s From 1872 until 1980 the United States government continually refused to recognize the sovereign status of the Grand Traverse Band of Ottawa and Chippewa Indians (GTB). 1 Citizens of the Grand(More)
Recent studies have suggested the relevance of different energy metabolic pathways in the balance between protective T cell immunity and T cell anergy in tumors. We and others have suggested the role of the depletion of the non-essential amino acid L-arginine as a mechanism for the induction of T cell suppression in tumors. Therefore, we hypothesize that it(More)
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