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A cAMP-response element binding protein-induced microRNA regulates neuronal morphogenesis.
TLDR
Evidence is provided that miR132 regulates neuronal morphogenesis by decreasing levels of the GTPase-activating protein, p250GAP, which reveals that a CREB-regulated miRNA regulates neuronal Morphogenesis by responding to extrinsic trophic cues. Expand
Homeostatic regulation of MeCP2 expression by a CREB-induced microRNA
TLDR
It is found that MeCP2 translation is regulated by microRNA 132 (miR132) and this feedback loop may provide a mechanism for homeostatic control of Me CP2 expression. Expand
PSD-95 is required for activity-driven synapse stabilization
TLDR
It is found that acute knockdown of PSD-95 in brain slice cultures by RNAi arrests the normal development of synaptic structure and function that is driven by spontaneous activity, and data support a model in which appropriate levels of PSd-95 are required for activity-dependent synapse stabilization after initial phases of synaptic potentiation. Expand
Presynaptic Protein Synthesis Is Required for Long-Term Plasticity of GABA Release
TLDR
Paired whole-cell recordings in rodent hippocampal slices suggest that presynaptic local protein synthesis controls neurotransmitter release during long-term plasticity in the mature mammalian brain. Expand
Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution
TLDR
The results suggest that AMPAR surface expression, but not its intracellular production or accumulation, is critical for regulating synaptic transmission. Expand
RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites
TLDR
A role for Sam68 is identified in synaptodendritic posttranscriptional regulation of actb and may provide insight into the pathophysiology of fragile X tremor/ataxia syndrome. Expand
Role reversal: the regulation of neuronal gene expression by microRNAs
TLDR
The accumulating evidence suggests that microRNAs are ubiquitous regulators of gene expression during development and are able to tune the expression of proteins on a global level in a manner that cannot be achieved by transcription factors alone. Expand
Opioid system is necessary but not sufficient for antidepressive actions of ketamine in rodents
TLDR
In a rat model of human depression, opioid antagonists abolish the ability of ketamine to reduce the depression-like behavioral and LHb hyperactive cellular phenotypes, suggesting that interactions between these two neurotransmitter systems are necessary to achieve an antidepressant effect. Expand
Coordination between Translation and Degradation Regulates Inducibility of mGluR-LTD
TLDR
This study finds that mGluR-LTD can be induced in the absence of translation if the proteasome is concurrently inhibited, and proposes that Sam68-mediated translation helps to counterbalance degradation, ensuring that protein levels briefly remain above a permissive threshold during LTD induction. Expand
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