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The Pathway Interaction Database (PID, http://pid.nci.nih.gov) is a freely available collection of curated and peer-reviewed pathways composed of human molecular signaling and regulatory events and key cellular processes. Created in a collaboration between the US National Cancer Institute and Nature Publishing Group, the database serves as a research tool(More)
The Ugandan national control programme for schistosomiasis has no clear policy for inclusion of preschool-children (</=5 years old) children. To re-balance this health inequality, we sought to identify best diagnosis of intestinal schistosomiasis, observe treatment safety and efficacy of praziquantel (PZQ), and extend the current WHO dose pole for(More)
The majority of digital games available today offer a variety of multi-player settings including co-located and mediated play between opponents. Immersion, the sense of being " in the game, " is one of the key components of the gaming experience but existing literature suggests that social play provides more fun but less immersion. There is however little(More)
We study the complex of partial bases of a free group, which is an analogue for Aut(Fn) of the curve complex for the mapping class group. We prove that it is connected and simply connected, and we also prove that its quotient by the Torelli subgroup of Aut(Fn) is highly connected. Using these results, we give a new, topological proof of a theorem of Magnus(More)
The Birman exact sequence describes the effect on the mapping class group of a surface with boundary of gluing discs to the boundary components. We construct an analogous exact sequence for the automorphism group of a free group. For the mapping class group, the kernel of the Birman exact sequence is a surface braid group. We prove that in the context of(More)
The Alliance for Cellular Signaling (AfCS)-Nature Molecule Pages will be a comprehensive database of key facts about more than 3,000 proteins involved in cell signalling. Each entry will be created by invited experts and be peer-reviewed. Alongside the large-scale experiments being conducted by the AfCS scientists, the wealth of information contained in(More)
The BRCT-domain protein Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by physically coupling the Rad9-Rad1-Hus1 clamp, the Rad3(ATR) -Rad26(ATRIP) kinase complex, and the Crb2(53BP1) mediator. We have now determined crystal structures of the BRCT repeats of Rad4(TopBP1), revealing a distinctive domain(More)
53BP1 plays multiple roles in mammalian DNA damage repair, mediating pathway choice and facilitating DNA double-strand break repair in heterochromatin. Although it possesses a C-terminal BRCT2 domain, commonly involved in phospho-peptide binding in other proteins, initial recruitment of 53BP1 to sites of DNA damage depends on interaction with histone(More)