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AIMS Pulmonary vein isolation (PVI) is the mainstay of interventional treatment of paroxysmal atrial fibrillation (PAF). We report on the feasibility and efficacy of a novel, open-irrigated mapping and radiofrequency (RF) ablation catheter. METHODS AND RESULTS Thirty-nine consecutive patients (pts; age 60 ± 10 years, 8 females) suffering from(More)
BACKGROUND The underlying mechanisms sustaining human persistent atrial fibrillation (PsAF) is poorly understood. OBJECTIVES This study sought to investigate the complexity and distribution of AF drivers in PsAF of varying durations. METHODS Of 135 consecutive patients with PsAF, 105 patients referred for de novo ablation of PsAF were prospectively(More)
BACKGROUND Specific noninvasive signal processing was applied to identify drivers in distinct categories of persistent atrial fibrillation (AF). METHODS AND RESULTS In 103 consecutive patients with persistent AF, accurate biatrial geometry relative to an array of 252 body surface electrodes was obtained from a noncontrast computed tomography scan. The(More)
BACKGROUND This study aimed to determine 5-year efficacy of catheter ablation for persistent atrial fibrillation (AF) using AF termination as a procedural end point. METHODS AND RESULTS One hundred fifty patients (57±10 years) underwent persistent AF ablation using a stepwise ablation approach (pulmonary vein isolation, electrogram-guided, and linear(More)
Atrial fibrillation (AF) is the manifest outcome of a multifactorial, progressive disease process,secondarily or primarily involving the atrial chambers. The slowly progressive electrostructural alterations diffusely involve the atrial substrate and lead to persistent and permanent forms of AF. Although the progression of the AF disease process is variable(More)
BACKGROUND Inferolateral early repolarization (ER) and Brugada syndrome manifest with J waves. Isoproterenol suppresses recurrent ventricular arrhythmias while reducing J waves in both disorders. OBJECTIVE To characterize the effect of isoproterenol on J waves. METHODS We analyzed the impact of isoproterenol on J waves in 20 patients with Brugada-type(More)
BACKGROUND A majority of patients undergoing ablation of ventricular tachycardia have implanted devices precluding substrate imaging with delayed-enhancement MRI. Contrast-enhanced multidetector computed tomography (MDCT) can depict myocardial wall thickness with submillimetric resolution. We evaluated the relationship between regional myocardial wall(More)
BACKGROUND Although the Task Force Criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) have recently been updated, the diagnosis remains challenging in the early stages. The aim of this study was to evaluate the diagnostic value of β-adrenergic stimulation in ARVC. METHODS AND RESULTS We evaluated 412 consecutive patients (213 men, age(More)