Matthew D. Smith

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Techniques for measurement of oxygen consumption rates of hepatocytes during attachment and post-attachment.

Matthew D. Smith, A D Smirthwaite, David E. Cairns, Rick Cousins, John D. S. Gaylor
The International journal of artificial organs
1996

Three techniques for measuring oxygen consumption rate (OCR) of cultured cells relevant to the development of bioartificial liver devices are reported. In an oxystat apparatus, HepG2 cells… (More)

Treatment of acute liver failure: hybrid liver support

Brad Busse, Matthew D. Smith, John Gerlach
Langenbeck's Archives of Surgery
1999

Hybrid liver support systems, which combine living cells of the liver in an extracorporeal circuit, have entered the first clinical trials in patients with acute liver failure. The goal of the… (More)

The influence of medium composition on the maintenance of cytochrome P-450, glutathione content and urea synthesis: a comparison of rat and sheep primary hepatocyte cultures.

Patricia L. Watts, Matthew D. Smith, Iris Edwards, Vivienne C. Zammit, Vanessa Brown, Helen M Grant
Journal of hepatology
1995

Rat and sheep primary hepatocytes have been cultured in four different medium formulations: Williams' E, Chee's, Medium 199 and Modified Earle's. The total cytochrome P450 content, intracellular… (More)

Augmentation of glucose induced insulin secretion by pertussis vaccine, phentolamine and benextramine: involvement of mechanisms additional to prevention of the inhibitory actions of catecholamines…

Matthew D. Smith, Brian L. Furman
Acta endocrinologica
1988

Pertussis vaccine, pertussis toxin, and the alpha-adrenoceptor blocking drug phentolamine augment glucose-induced insulin secretion. The present study was carried out to determine the relationship… (More)

Oxygen transfer in a diffusion-limited hollow fiber bioartificial liver.

Phil Hay, A Roy Veitch, Matthew D. Smith, Rick Cousins, John D. S. Gaylor
Artificial organs
2000

A mathematical model was developed to predict oxygen transport in a hollow fiber bioartificial liver device. Model parameters were taken from the Hepatix ELAD configuration; a blood perfused hollow… (More)

Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies.

Joerg C. Gerlach, Norbert Schnoy, Jens Encke, Matthew D. Smith, Christian Müller, Peter Neuhaus
Hepatology
1995

Primary pig hepatocytes form a tissuelike structure in an in vitro culture model that has provision for three-dimensional cell orientation, cell aggregation, decentralized cell perfusion with low… (More)

Novel quantitative methods for the determination of biomaterial cytotoxicity.

Matthew D. Smith, J. C. Barbenel, James Courtney, Margaret H. Grant
The International journal of artificial organs
1992

Two novel methods for the determination of biomaterial cytotoxicity using cell culture are presented. The methods combine a standardized protocol for producing extracts from medical devices with… (More)

The effect of blood transfusion on T-suppressor cells in renal dialysis patients.

Matthew D. Smith, John David Williams, Gerald A. Coles, JohnR. Salaman
Transplantation proceedings
1981

Hepatocyte culture between woven capillary networks: a microscopy study.

Joerg C. Gerlach, Norbert Schnoy, Matthew D. Smith, Peter Neuhaus
Artificial organs
1994

A multi-compartment capillary membrane culture model with independently perfused three-dimensionally woven capillaries was developed for immobilization of hepatocytes in bioreactors. This enables… (More)

The European Union Concerted Action World Wide Web site for Lyme borreliosis.

Matthew D. Smith, George Gettinby, +5 authors Gerold Stanek
Zentralblatt fur Bakteriologie : international…
1998

This web site (URL http://www.dis.strath.ac.uk/vie/LymeEU/) provides information on Lyme borreliosis for physicians, scientists, health care workers, veterinarians and students. It consists of a… (More)

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