Matthew D Fry

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Human furin catalyzes the proteolytic maturation of many proproteins in the exocytic and endocytic secretory pathways by cleavage at the C-terminal side of the consensus sequence-ArgXaaLys/ArgArg decreases -. Both the trans-Golgi network (TGN) concentration and intracellular routing of furin require sequences in its 56 amino acid cytoplasmic tail. Here, we(More)
Phorbol esters such as 12-O-tetradeconylphorbol-13-acetate (TPA) activate protein kinase C, increase Connexin43 (Cx43) phosphorylation, and decrease cell-cell communication via gap junctions in many cell types. Previous work has implicated protein kinase C (PKC) in the direct phosphorylation of Cx43 at S368, which results in a change in single channel(More)
N accessible shale deposits have dramatically increased global gas reserves and are touted as a bridge to a clean energy future. For example, in the U.S., where shale gas is projected to comprise 49% of national natural gas production by 2035, proponents argue that shale gas production can provide energy independence, create employment, and stimulate(More)
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