Matthew Coelho

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In eukaryotes, the covalent attachment of ubiquitin chains directs substrates to the proteasome for degradation. Recently, ubiquitin-like modifications have also been described in the archaeal domain of life. It has subsequently been hypothesized that ubiquitin-like proteasomal degradation might also operate in these microbes, since all archaeal species(More)
In this paper we explore the design of an analytical framework for quantifying financial loss in the aftermath of catastrophic events. The idea is to aggregate the thousands of exposure databases received by a single reinsurer into a giant loosely structured exposure portfolio and then use Big Data analysis technology, originally developed in the context of(More)
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