Matthew C Skeels

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Even though amatoxins and phallotoxins have been well characterized in basidiocarps of Amanita species, to our knowledge no report of these toxins in spores of Amanitas has been published. Reversed phase HPLC was used to determine non-zero concentrations of alpha-amanitin (0.30 mg/g), and phallacidin (0.02 mg/g) in spores taken from white Amanita sect.(More)
The leucine-isoleucine-valine binding protein (LIV) found in the periplasmic space of E. coli has been used as a structural model for a number of neuronal receptors. This "venus fly trap" type protein has been characterized by crystallography in only the open form. Herein we have labeled LIV with 5-fluorotryptophan (5F-Trp) and difluoromethionine (DFM) in(More)
The ostium of the coronary sinus opens directly into the right atrium in close proximity to the insertion of the atrioventricular values. If the coronary sinus is dilated, it can create the appearance of atrioventricular canal defect in the fetal echocardiographic four-chamber view. The diagnosis of a serious heart lesion, such as a canal defect,(More)
BACKGROUND The growing popularity of Chinese herbal medicine in the United States has prompted large-scale import of raw herbs from Asia. Many of the Asian herbs have phylogenetically related North American species. We compared three phylogenetically related species, namely Coptis chinensis (Huanglian), Hydrastis canadensis and Coptis trifolia to show(More)
At the University of California Davis Medical Center, a screening fetal ultrasound examination (level I or II) incorporates a comprehensive segmental evaluation of the fetal heart. This study evaluated the reliability of the fetal ultrasound exam in the detection of abnormal heart anatomy. Our retrospective study reviewed results of 614 antenatal patients(More)
Spectroscopic methods were used to monitor the unfolding of the leucine specific (LS) and the leucine-isoleucine-valine (LIV) binding proteins. Our studies indicate that ligand-free protein undergoes a simple two-state unfolding, whereas the protein-ligand complex undergoes a three-state unfolding model. Ligand binding causes significant stabilization of(More)
Thrombomodulin (TM) is a membrane glycoprotein in the vascular endothelium which shows a high affinity to thrombin. The thrombomodulin-thrombin complex induces coagulation by the activation of protein C, which, in turn, inactivates the intrinsic pathway plasma factors V and VIII, finally blocking the formation of new thrombin (Sadler, 1997). TM is mainly(More)
In vivo study of nanomaterials is complicated by the physical and chemical changes induced in the nanomaterial by exposure to biological compartments. A diverse array of proteins can bind to the nanomaterial, forming a protein corona which may alter the dispersion, surface charge, distribution, and biological activity of the material. Evidence suggests that(More)
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