Matthew C. Clark

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The therapeutic value of many drugs can be limited by gastrointestinal (GI) adverse effects such as nausea and vomiting. Nausea is a subjective human sensation, hence little is known about preclinical biomarkers that may accurately and effectively predict its presence in man. The aim of this analysis was to use informatics and data-mining tools to identify(More)
BACKGROUND Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in(More)
The Mediterranean variant of glucose-6-phosphate dehydrogenase (G6PD) is functionally deficient and found in a variety of cell types of affected individuals, including both erythocytes and neutrophils. To determine if the presence of this sex-linked gene is associated to any degree with the occurrence of severe bacterial infection, a study of hospitalized(More)
The incidence of brain tumors is increasing rapidly particularly in the young generation. Tumors can directly destroy all healthy brain cells. Manual (Physical) classification can cause human error. Automatic classification method is required because it reduces the load on the human observer, accuracy is not affected due to large number of images. This(More)
Automatic Brain Tumor Detection refers to the problem of delineating tumorous tissues from MRI images for the purpose of medical diagnosis and surgical planning. The process uses tumor characteristics in images, such as sizes, shapes, locations and intensities for the isolation of the tumor which depends on manual tracing by experts. This paper proposes(More)
— A system that automatically segments and labels glioblastoma-multiforme tumors in magnetic resonance images (MRI's) of the human brain is presented. The MRI's consist of T 1-weighted, proton density, and T 2-weighted feature images and are processed by a system which integrates knowledge-based (KB) techniques with multispectral analysis. Initial(More)
BACKGROUND Inflammatory bowel disease (IBD) is well recognized in developed countries and is generally among the differential diagnoses of young patients presenting with refractory diarrhea once other more common etiologies have been excluded. Pinworm infections, on the other hand, are not as common among adults in the United States. CASE REPORT Based on(More)