Matthew C. Clark

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Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the pocket leads to a loss or switch in the function of yeast or(More)
BACKGROUND Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in(More)
This paper presents a system that integrates a knowledge-based system with unsupervised fuzzy clustering to automatically segment and label glioblastoma multiforme tumors in magnetic resonance slices of the human brain. Each slice is initially segmented by an unsupervised fuzzy c-means algorithm. The segmented image, along with a set of tissue cluster(More)
The incidence of brain tumors is increasing rapidly particularly in the young generation. Tumors can directly destroy all healthy brain cells. Manual (Physical) classification can cause human error. Automatic classification method is required because it reduces the load on the human observer, accuracy is not affected due to large number of images. This(More)
To detect the tumor in the brain is very important task but the major problem occurred is that its very time consuming. We provide an approach towards the automation of this process in this paper. We take magnetic resonance images of the brain as a input and attempt to calculated the position and the size of the tumor. Each pixel in each slice will be(More)
High Harmonic Generation is a non-linear process that enables the tabletop production of coherent laser-like beams in the extreme ultraviolet and soft x-ray regions of the electromagnetic spectrum. In order to achieve significant high harmonic flux, the generated high harmonics must be phase matched. We achieve this by coupling the incident driving laser(More)