Matthew C. Clark

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Previous work has shown that mGlu2/3 receptor agonists such as LY379268 inhibit motor responses to acutely administered phencyclidine (PCP) in rats. However, it has not been determined whether mGlu2/3 receptor agonists will reverse the enhanced effects of repeatedly administered PCP (so called PCP sensitization). In these studies, rats were administered(More)
This study was designed to determine whether the subjective, behavioral or physiological effects of a stimulant drug in humans depend on whether subjects are tested under isolated or social conditions. Forty-two subjects were randomly assigned to either the Social (SOC) or Isolated (ISO) condition. SOC subjects participated in 4 h laboratory sessions in(More)
BACKGROUND Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in(More)
The incidence of brain tumors is increasing rapidly particularly in the young generation. Tumors can directly destroy all healthy brain cells. Manual (Physical) classification can cause human error. Automatic classification method is required because it reduces the load on the human observer, accuracy is not affected due to large number of images. This(More)
Automatic Brain Tumor Detection refers to the problem of delineating tumorous tissues from MRI images for the purpose of medical diagnosis and surgical planning. The process uses tumor characteristics in images, such as sizes, shapes, locations and intensities for the isolation of the tumor which depends on manual tracing by experts. This paper proposes(More)
The Effects of Beam Stabilization on Mode Coupling in a Hollow Cylindrical Waveguide" (2013). A senior undergraduate thesis submitted to the University of Colorado at Boulder Physics Department partially fulfilling the requirements to graduate with latin honors. Abstract High Harmonic Generation is a non-linear process that enables the tabletop production(More)
To detect the tumor in the brain is very important task but the major problem occurred is that its very time consuming. We provide an approach towards the automation of this process in this paper. We take magnetic resonance images of the brain as a input and attempt to calculated the position and the size of the tumor. Each pixel in each slice will be(More)