Matthew C. Clark

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Raf kinase inhibitory protein (RKIP/PEBP1), a member of the phosphatidylethanolamine binding protein family that possesses a conserved ligand-binding pocket, negatively regulates the mammalian mitogen-activated protein kinase (MAPK) signaling cascade. Mutation of a conserved site (P74L) within the pocket leads to a loss or switch in the function of yeast or(More)
BACKGROUND Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding Protein family, negatively regulates growth factor signaling by the Raf/MAP kinase pathway. Since an organic compound, locostatin, was reported to bind RKIP and inhibit cell migration by a Raf-dependent mechanism, we addressed the role of RKIP in(More)
The incidence of brain tumors is increasing rapidly particularly in the young generation. Tumors can directly destroy all healthy brain cells. Manual (Physical) classification can cause human error. Automatic classification method is required because it reduces the load on the human observer, accuracy is not affected due to large number of images. This(More)
To detect the tumor in the brain is very important task but the major problem occurred is that its very time consuming. We provide an approach towards the automation of this process in this paper. We take magnetic resonance images of the brain as a input and attempt to calculated the position and the size of the tumor. Each pixel in each slice will be(More)
— A system that automatically segments and labels glioblastoma-multiforme tumors in magnetic resonance images (MRI's) of the human brain is presented. The MRI's consist of T 1-weighted, proton density, and T 2-weighted feature images and are processed by a system which integrates knowledge-based (KB) techniques with multispectral analysis. Initial(More)
The stresses in various sections of two-dimensional models of the elbow joint, without and with a prosthesis (the humeral component of a total elbow prosthesis), were obtained using the finite element analysis method. Three parameters were varied: type of applied load; method of fixation of the prosthesis to the contiguous bone; and shape of the head of the(More)