Matthew Ball

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There are many arguments for and against the use of autonomous-agents in intelligent environments. Some researchers maintain that it is of utmost importance to give complete control to users, and hence greatly restrict autonomy of agents, whereas, others believe that is it preferable to increase user convenience by allowing agents to operate autonomously on(More)
In intelligent environment research, many believe that we should focus on developing end-user driven systems, seeking to empower the user, whereas, many others maintain that intelligent environments should be autonomous-agent driven, minimising user cognitive loading. We however, follow the premise that users of intelligent environments should be given a(More)
As Intelligent Environments research continues in its various guises, there is an increase in the scale at which investigation is being conducted. Projects are looking beyond single-room and apartment sized living-labs that have provided us with initial testbeds for early research and are envisioning grander designs on the scale of entire buildings, campus(More)
There is a long-standing debate over the role that intelligent agents should play and how much autonomy they should be given in user-centric systems such as intelligent environments and other pervasive computing technologies. A recent online survey has been conducted to assess people's opinions of the use of autonomy in intelligent environments. In order to(More)
The enantioselective total synthesis of thapsigargin, a potent, selective inhibitor of the Ca2+ pump SERCA, is described. Starting from ketoalcohol 8, key steps involve regioselective introduction of the internal olefin at C4-C5, judicious protecting group choice to allow chelation-controlled reduction at C3, and chemoselective introduction of the angelate(More)
Thapsigargin is a densely oxygenated guaianolide which displays potent sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) binding affinities. The total syntheses of designed unnatural analogues of this important natural product are described. This article constitutes the chemical synthesis behind an ongoing project. Rational modifications have been made to(More)
Herein we describe the total synthesis of five guaianolide natural products: thapsigargin, thapsivillosin C, thapsivillosin F, trilobolide and nortrilobolide. Prodrug derivatives of thapsigargin have shown selective in vivo cytotoxicity against prostate tumours and the need for further investigation of this phenomenon highlights the importance of these(More)
Autonomy of embedded agents in intelligent environments is highly debated topic; while some believe that agents should have very minimal autonomy and should only act as directly instructed by the user, others consider providing agents with autonomy to be an essential aspect to building intelligent environments. This paper reports on the current progress of(More)
In this short conceptual paper we explore the need for demonstrations of intelligent environments research that can convey what we as researchers think to potential users that have limited exposure to such ideas. This is especially important where physical and virtual worlds meet in the smart home context. We present several exemplars that are intended to(More)