Matthew B. Singer

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  • Irfan Nooruddin, Pradeep Chhibber, Carew Boulding, Robert Kaufman, Herbert Kitschelt, Craig Mcintosh +8 others
  • 2007
What explains variations in electoral volatility? The authors argue that fiscal space—availability of financial resources to enact policy initiatives and provide public programs—possessed by governments can explain the level of electoral volatility. Where governments have fiscal space, citizens reward incumbent parties with their continued support. But when(More)
The wide spectrum of vitamin D activity has focused attention on its potential role in the elevated burden of disease in a northern Canadian First Nations (Dené) cohort. Vitamin D insufficiency, and gene polymorphisms in the vitamin D receptor (VDR) and vitamin D binding protein (VDBP) have been implicated in susceptibility to infectious and chronic(More)
BACKGROUND Increased awareness of the wide spectrum of activity of vitamin D has focused interest on its role in the health of Canada's Aboriginal peoples, who bear a high burden of both infectious and chronic disease. Cutaneous vitamin D synthesis is limited at northern latitudes, and the transition from nutrient-dense traditional to nutrient-poor market(More)
Traumatic brain injury (TBI) is an enormous public health problem, with 1.7 million new cases of TBI recorded annually by the Centers for Disease Control. However, TBI has proven to be an extremely challenging condition to treat. Here, we apply a nanoprodrug strategy in a mouse model of TBI. The novel nanoprodrug contains a derivative of the nonsteroidal(More)
BACKGROUND Canadian First Nation populations have experienced endemic and epidemic tuberculosis (TB) for decades. Vitamin D-mediated induction of the host defence peptide LL-37 is known to enhance control of pathogens such as Mycobacterium tuberculosis. OBJECTIVE Evaluate associations between serum levels of 25-hydroxy vitamin D (25(OH)D) and LL-37, in(More)
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