Matthew-Alan Roberts

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The biomedical community is developing new methods of data analysis to more efficiently process the massive data sets produced by microarray experiments. Systematic and global mathematical approaches that can be readily applied to a large number of experimental designs become fundamental to correctly handle the otherwise overwhelming data sets. The gene(More)
Foods are not purified compounds acting on single molecular targets, but complex mixtures of molecules that modulate many biochemical pathways simultaneously. Diet affects the probability of developing various diseases. Nevertheless, specific recommendations for individual diets are not simple. Recommending nutrient intakes above and beyond those needed to(More)
The functions, actions, and regulation of polyunsaturated fatty acids (PUFAs) are just now beginning to be unraveled, in large due to modern molecular techniques. In the present work, mice were fed diets rich in either arachidonic acid (AA, n6), docosahexaenoic acid (DHA, n3), or the combination (AA+DHA). Both liver and hippocampus tissue were then analyzed(More)
The ATP-binding cassette (ABC) family of proteins comprise a group of membrane transporters involved in the transport of a wide variety of compounds, such as xenobiotics, vitamins, lipids, amino acids, and carbohydrates. Determining their regional expression patterns along the intestinal tract will further characterize their transport functions in the gut.(More)
Nutrition is traditionally a multidisciplinary field applying principles of molecular biochemistry and statistical epidemiology to integrative metabolism and population health. Genomics, with its global perspective, is now reinventing the future of human metabolic health. Creative experimental designs are addressing metabolic questions in nutrition ranging(More)
The purpose of this work was to characterize the expression of drug and nutrient carriers along the anterior-posterior and crypt-villus axes of the intestinal epithelium and to study the validity of utilizing whole gut tissue rather than purified epithelial cells to examine regional variations in gene expression. We have characterized the mRNA expression(More)
Nutrition research is in the process of addressing a series of questions related to the future of diet and health. Are all humans the same with respect to their response to diet? If not, humans must be fed differently according to the differences in their genetics and metabolic needs. Are those differences self-evident to the individual or their(More)
The biomedical community is rapidly developing new methods of data analysis for microarray experiments, with the goal of establishing new standards to objectively process the massive datasets produced from functional genomic experiments. Each microarray experiment measures thousands of genes simultaneously producing an unprecedented amount of biological(More)
The human genome has arrived. The technologies of global transcriptional analysis are building the greatest knowledge base in the history of biological science and the world is waiting impatiently for the benefits that this knowledge will provide. Discouragingly for nutrition, in the current public health environment, knowledge from genomics alone will not(More)
MOTIVATION Microarray technology has become a powerful research tool in many fields of study; however, the cost of microarrays often results in the use of a low number of replicates (k). Under circumstances where k is low, it becomes difficult to perform standard statistical tests to extract the most biologically significant experimental results. Other more(More)