Matthew A. Reyna

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Adenosine-to-inosine RNA editing is a highly conserved process that post-transcriptionally modifies mRNA, generating proteomic diversity, particularly within the nervous system of metazoans. Transcripts encoding proteins involved in neurotransmission predominate as targets of such modifications. Previous reports suggest that RNA editing is responsive to(More)
Discontinuous Galerkin (DG) and central DG methods are two related families of finite element methods. They can provide high order spatial discretizations that are often combined with explicit high order time discretizations to solve initial boundary value problems. In this context, it has been observed that the central DG method allows larger time steps,(More)
MOTIVATION The somatic mutations in the pathways that drive cancer development tend to be mutually exclusive across tumors, providing a signal for distinguishing driver mutations from a larger number of random passenger mutations. This mutual exclusivity signal can be confounded by high and highly variable mutation rates across a cohort of samples. Current(More)
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