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Phototropins (phot1 and phot2) are plasma membrane-associated receptor kinases that respond specifically to blue and UV wavelengths. In addition to a C-terminal Ser/Thr kinase domain, phototropins contain two N-terminal chromophore binding LOV domains that function as photoswitches to regulate a wide range of enzymatic activities in prokaryotes and(More)
Circadian clocks are near-ubiquitous molecular oscillators that coordinate biochemical, physiological, and behavioral processes with environmental cues, such as dawn and dusk. Circadian timing mechanisms are thought to have arisen multiple times throughout the evolution of eukaryotes but share a similar overall structure consisting of interlocking(More)
Circadian rhythms provide organisms with an adaptive advantage, allowing them to regulate physiological and developmental events so that they occur at the most appropriate time of day. In plants, as in other eukaryotes, multiple transcriptional feedback loops are central to clock function. In one such feedback loop, the Myb-like transcription factors CCA1(More)
By coupling a probe transition to a Rydberg state using electromagnetically induced transparency (EIT) we map the strong dipole-dipole interactions onto an optical field. We characterize the resulting cooperative optical nonlinearity as a function of probe strength and density. We demonstrate good quantitative agreement between the experiment and an N-atom(More)
By illuminating an individual rubidium atom stored in a tight optical tweezer with short resonant light pulses, we created an efficient triggered source of single photons with a well-defined polarization. The measured intensity correlation of the emitted light pulses exhibits almost perfect antibunching. Such a source of high-rate, fully controlled(More)
Quantum computers have the capability of out-performing their classical counterparts for certain computational problems 1. Several scalable quantum-computing architectures have been proposed. An attractive architecture is a large set of physically independent qubits arranged in three spatial regions where (1) the initialized qubits are stored in a register,(More)
When two indistinguishable single photons are fed into the two input ports of a beam splitter, the photons will coalesce and leave together from the same output port. This is a quantum interference effect, which occurs because two possible paths-in which the photons leave by different output ports-interfere destructively. This effect was first observed in(More)
PURPOSE We used sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the medical treatment of human cataract. METHODS The macrocyclic aldehyde, CAT811, identified previously as a calpain inhibitor that prevents calcium-induced opacification in cultured sheep(More)
Community policing is intended to empower citizens who are plagued by crime and disorder. Scholars have considered community policing as a proactive measure that addresses issues of disorder to prevent the occurrence of more serious crimes (Goldstein, 1986; Wilson & Kelling, 1982). In a digital age, people are increasingly interacting socially via web(More)
The circadian system induces rhythmic variation in a suite of biochemical and physiological processes that serve to optimise plant growth in diel cycles. To be of greatest utility, these rhythmic behaviors are coordinated with regular environmental changes such as the rising and setting of the sun. Photoreceptors, along with metabolites produced during(More)