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Circadian clocks are near-ubiquitous molecular oscillators that coordinate biochemical, physiological, and behavioral processes with environmental cues, such as dawn and dusk. Circadian timing mechanisms are thought to have arisen multiple times throughout the evolution of eukaryotes but share a similar overall structure consisting of interlocking(More)
Circadian rhythms provide organisms with an adaptive advantage, allowing them to regulate physiological and developmental events so that they occur at the most appropriate time of day. In plants, as in other eukaryotes, multiple transcriptional feedback loops are central to clock function. In one such feedback loop, the Myb-like transcription factors CCA1(More)
OBJECTIVE To identify activation patterns of several muscles acting on the shoulder joint during isokinetic internal and external rotation. DESIGN Combined EMG and isokinetic strength analysis in healthy subjects. BACKGROUND EMG studies of the shoulder region revealed intricate muscular activation patterns during elevation of the arm but no parallel(More)
It is widely considered that biological maturity influences physical fitness test performance, children can be advantaged/disadvantaged in physical fitness tests by being more or less mature than counterparts of the same chronological age. The current study sought to investigate the effect sexual maturity had upon performance in physical fitness tests. A(More)
PURPOSE We used sheep with an autosomal dominant gene for cortical cataract as an animal model to evaluate novel macrocyclic calpain inhibitors with potential for the medical treatment of human cataract. METHODS The macrocyclic aldehyde, CAT811, identified previously as a calpain inhibitor that prevents calcium-induced opacification in cultured sheep(More)
Altered dynamic control appears to be a significant contributing factor to shoulder dysfunction. The shoulder relies primarily on the rotator cuff for dynamic stability through mid-range. Hence, any impairment in the dynamic stabilizing system is likely to have profound effects on the shoulder complex. The rotator cuff appears to function as a deep(More)
Community policing is intended to empower citizens who are plagued by crime and disorder. Scholars have considered community policing as a proactive measure that addresses issues of disorder to prevent the occurrence of more serious crimes (Goldstein, 1986; Wilson & Kelling, 1982). In a digital age, people are increasingly interacting socially via web(More)
The circadian system induces rhythmic variation in a suite of biochemical and physiological processes that serve to optimise plant growth in diel cycles. To be of greatest utility, these rhythmic behaviors are coordinated with regular environmental changes such as the rising and setting of the sun. Photoreceptors, along with metabolites produced during(More)
In the course of the development of calpain inhibitors, we report the synthesis of eight-membered cyclic pseudo dipeptides closely related to the known inhibitor SJA6017. The ring closure was effected by metathesis of the diallyl-substituted dipeptides 6 and 7. The formation of the dipeptides under kinetic control leads to the preferential formation of the(More)
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