Cartilage tissue engineering has primarily focused on the generation of grafts to repair cartilage defects due to traumatic injury and disease. However engineered cartilage tissues have also a strong scientific value as advanced 3D culture models. Here we first describe key aspects of embryonic chondrogenesis and possible cell sources/culture systems for in… (More)
The development of in vitro models to screen the effect of different concentrations, combinations and temporal sequences of morpho-regulatory factors on stem/progenitor cells is crucial to investigate and possibly recapitulate developmental processes with adult cells. Here, we designed and validated a microfluidic platform to (i) allow cellular… (More)
Myocardial infarction and its consequences represent one of the most demanding challenges in cell therapy and regenerative medicine. Transfer of skeletal myoblasts into decompensated hearts has been performed through intramyocardial injection. However, the achievements of both cardiomyocyte differentiation and precise integration of the injected cells into… (More)
Introduction Vascular tissue engineering is a promising strategy with a broad spectrum of potential applications, but many hurdles still need to be overcome . To this extent, we developed a PLLA/PCL scaffold releasing heparin by a combination of electrospinning and fused deposition modelling (FDM) technique.
The community of scientists, politicians, and regulators around the field of stem cell biology has been shocked by the sudden death of Paolo Bianco and by the loss of a passionate, rigorous, deeply honest, inspiring man. We would like to remember Paolo with the eyes of students, as we were when we met him for the first time. The features of his personality… (More)