Matteo Bianchi

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Chronic granulomatous disease (CGD) patients have impaired nicotinamide adenine dinucleotide phosphate (NADPH) oxidase function, resulting in poor antimicrobial activity of neutrophils, including the inability to generate neutrophil extracellular traps (NETs). Invasive aspergillosis is the leading cause of death in patients with CGD; it is unclear how(More)
BACKGROUND Aspergillus spp infection is a potentially lethal disease in patients with neutropenia or impaired neutrophil function. We showed previously that Aspergillus hyphae, too large for neutrophil phagocytosis, are inhibited by reactive oxygen species-dependent neutrophil extracellular trap (NET) formation. This process is defective in chronic(More)
Various models of HIV infection and evolution have been considered in the literature. This paper considers a variant of the Wodarz and Nowak mathematical model, adding "aggressiveness" as a new state variable in order to quantify the strength of the virus and its response to drugs. Although the model proposed is relatively simple, simulation results suggest(More)
While it is known that softness discrimination relies on both kinesthetic and cutaneous information, relatively little work has been done on the realization of haptic devices replicating the two cues in an integrated and effective way. In this paper, we first discuss the ambiguities that arise in unimodal touch, and provide a simple intuitive explanation in(More)
In this paper we study the problem of optimally designing glove–based sensing devices for hand pose reconstruction to maximize their potential for precision. In a companion paper we studied the problem of maximizing the reconstruction accuracy of the hand pose from partial and noisy data provided by any given pose sensing device (a sensorized “glove”)(More)
This paper describes a new bi-elastic fabric-based display for rendering softness. Bi-elastic means that the fabric exhibits properties which render it elastic in at least two substantially perpendicular directions, and preferably in all directions. The device described here is based on tissue stretch to provide different levels of softness. More(More)
How the human brain controls hand movements to carry out different tasks is still debated. The concept of synergy has been proposed to indicate functional modules that may simplify the control of hand postures by simultaneously recruiting sets of muscles and joints. However, whether and to what extent synergic hand postures are encoded as such at a cortical(More)
This paper presents a methodology to accurately record human finger postures during grasping. The main contribution consists of a kinematic model of the human hand reconstructed via magnetic resonance imaging of one subject that (i) is fully parameterized and can be adapted to different subjects, and (ii) is amenable to in-vivo joint angle recordings via(More)
UNLABELLED The majority of influenza virus-specific antibodies elicited by vaccination or natural infection are effective only against the eliciting or closely related viruses. Rare stem-specific heterosubtypic monoclonal antibodies (hMAbs) can neutralize multiple strains and subtypes by preventing hemagglutinin (HA)-mediated fusion of the viral membrane(More)
Conclusions Qualitative experimental validations show accuracy in estimating contact points (I) and position and orientation of fingertips (II). A quantitative validation (III), performed by comparison with a reliable reference, shows some small differences, which can be ascribed to the glove setup. Future work will involve performing a more thorough(More)