Matt Wiser

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This paper presents a case study of 3-to 9-year-old children's concepts of size, weight, density, matter, and material kind. Our goal was to examine two claims: (1) that individual concepts undergo differentiation during development ; and (2) that young children's concepts are embedded in theory-like structures. To make progress on the first issue, we(More)
The malarial parasite dramatically alters its host cell by exporting and targeting proteins to specific locations within the erythrocyte. Little is known about the mechanisms by which the parasite is able to carry out this extraparasite transport. The fungal metabolite brefeldin A (BFA) has been used to study the secretory pathway in eukaryotes. BFA(More)
Little is known about how the malaria parasite transports and targets proteins into the host erythrocyte. Parasite proteins exported into the host cell not only have to cross the parasite plasma membrane but also must traverse the parasitophorous vacuolar membrane (PVM) that surrounds the parasite. The PVM of Plasmodium chabaudi-infected erythrocytes was(More)
The merozoite surface protein-1 (MSP-1) is a relatively abundant protein which has been found in all Plasmodium species examined [1,2]. MSP-1 is synthesized as a high molecular mass (200 kDa) precursor protein which is proteolytically processed into smaller fragments. Proteolytic processing of MSP-1 is a two-step procedure characterized by primary and(More)
The complete gene for merozoite surface protein-1 (MSP-1) from Plasmodium berghei has been cloned and sequenced. Comparison of the P. berghei MSP-1 sequence with MSP-1 from other rodent parasites reveals five conserved domains interrupted by four variable blocks. These variable blocks exhibit no sequence homology but do have similar amino acid compositions.(More)
The malaria parasite extensively modifies the host erythrocyte. Many of these modifications are mediated by proteins exported from the parasite and targeted to specific locations within the infected erythrocyte. However, little is known about how the parasite targets proteins to specific locations beyond its own plasma membrane. Treatment of infected(More)
We examine a modified 2 × 2 game of Hex in which the winner of each cell is determined by a Tullock contest. The player establishing a winning path of cells in the game wins a fixed prize. Examining the polar cases of all cells being contested simultaneously versus all four cells being contested sequentially, we show that there is an increase in the total(More)
In this paper, we examine a modified 2 × 2 game of Hex in which control of each cell is determined by a Tullock contest. The player establishing a path of cells within his control between his two sides wins a fixed prize. Examining the polar cases of all cells being contested simultaneously versus all four cells being contested sequentially, we show that(More)
Proteases appear to be required for critical events in the erythrocytic life cycle of malaria parasites, including the rupture of erythrocytes by mature schizonts and the subsequent invasion of erythrocytes by daughter merozoites [1,2]. This conclusion is supported by studies showing that parasite rupture and invasion of erythrocytes are inhibited by serine(More)