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The present experiments investigated the hypothesis that lactation constitutes a chronic stress to the adrenocortical system. To determine whether the normal circadian control of the adrenocortical system or the ability to mount an adequate ACTH response to stress are modified during lactation, we compared morning and evening basal and stress-induced ACTH,(More)
In rats, angiotensin II appears to be synthesized in the anterior pituitary gland and stored in gonadotropes in the same granules as the beta-subunit of luteinizing hormone (LH). The gonadotropes also contain renin-like and angiotensin-converting enzyme-like immunoreactivity, but angiotensinogen-like immunoreactivity is found in a separate population of(More)
Utilizing an immunocytochemical technique wherein two different antigens can be visualized on the same tissue section, angiotensin-like immunoreactivity was found in rat adenohypophyseal cells that showed staining with antisera to hLH, hFSH or human prolactin. Angiotensin-like immunoreactivity was not found in cells that showed staining with antisera to(More)
We studied the effects of the estrous cycle, ovariectomy and estrogen replacement on angiotensin-converting enzyme (ACE) (kininase II, EC 3.4.15.1) and angiotensin II (AT) receptors in the pituitary gland of the female rat. Quantitative autoradiography, with the use of consecutive pituitary sections, allowed for simultaneous determination of changes in(More)
In anesthetized rats with sinoaortic denervation, intracerebroventricular (icv) injection of atrial natriuretic peptide (ANP) resulted in decreased mean arterial blood pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) (depressor effects), whereas icv angiotensin II (ANG II) produced increases in these variables (pressor effects).(More)
Angiotensin II (AII; 1.0 microliter of 10(-10) M) injected bilaterally into the anterior hypothalamus-preoptic area of the brain produced a 100% increase in mean whole blood LH concentrations in ovariectomized rats treated with estradiol and progesterone. Injections of equal volumes and concentrations of the peptide into the third cerebral ventricle or into(More)
Previously, we reported that intravenous (iv) administration of atrial natriuretic peptide (ANP) evokes a decrease in sympathetic outflow. This effect requires an afferent input from vagal C-fibers. Here, we examined the effect of intracerebroventricular (icv) administration of ANP on sympathetic outflow, as well as the potential role of central mechanisms(More)
Both norepinephrine (NE) and its major metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), were assayed in rat hypothalamus during selected stages of pregnancy and lactation. No changes were observed in the concentration of either NE or MHPG at 5, 15 or 21 days' gestation. However, with 8-15 h after parturition, the concentration of NE decreased sharply(More)