Matt Michal

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The effect of calcium dobesilate (calcium dihydroxy-2,5 benzenesulphonate) on thrombus formation in vivo was evaluated. Experimental thrombi were induced in a venule of a hamster cheek pouch following iontophoresis of adenosine diphosphate (ADP). Calcium dobesilate administered intraperitoneally as a single injection inhibited thrombus formation in a time-(More)
The hamster cheek pouch model of experimental thrombosis in which thrombi are induced in the microvasculature by iontophoretical administration of adenosine diphosphate (ADP) was used to test the antithrombotic potential of pentoxifylline (Trental). Single intraperitoneal injections of 5, 10 and 20 mg/kg pentoxifylline reduced thrombus formation by 20 to(More)
The effects of calcium dobesilate (Doxium, a drug already known to prevent or reverse the retinal microvascular lesions of diabetes mellitus) on sorbitol formation in human erythrocytes was studied, and compared with the effects of tetramethylene glutaric acid (TMGA), a specific aldose reductase inhibitor. Both compounds inhibited sorbitol formation. In a(More)
We investigate a remarkable class of exponential sums which are derived from the symmetric groups and which display a diverse array of visually appealing features. Our interest in these expressions stems not only from their astounding visual properties, but also from the fact that they represent a novel and intriguing class of supercharacters.
Platelet-active drugs are of potential benefit in prevention of diabetic microangiopathy as well as other thromboembolic complications. The present investigation examines the effect of an angio-protective agent, calcium dobesilate (Doxium) on platelets and suggests its mechanism of action. Calcium dobesilate reduces aggregation and the release reaction(More)
Properties of two of the stochastic circulatory models theoretically introduced by Smith et al., 1997, Bull. Math. Biol. 59, 1-22 were investigated. The models assumed the gamma distribution of the cycle time under either the geometric or Poisson elimination scheme. The reason for selecting these models was the fact that the probability density functions of(More)
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