Matt Holzer

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We investigate the problem of attractor reconstruction from interspike times produced by an integrate-and-fire model of neuronal activity. Suzuki et. al. [14] found that the reconstruction of the Rössler attractor is incomplete if the integrate-and-fire model is used. We explain this failure using two observations. One is that the attractor reconstruction(More)
This article is concerned with pointwise growth and spreading speeds in systems of parabolic partial differential equations. Several criteria exist for quantifying pointwise growth rates. These include the location in the complex plane of singularities of the pointwise Green's function and pinched double roots of the dispersion relation. The primary aim of(More)
We identify a new mechanism for propagation into unstable states in spatially extended systems, that is based on resonant interaction in the leading edge of invasion fronts. Such resonant invasion speeds can be determined solely based on the complex linear dispersion relation at the unstable equilibrium, but rely on the presence of a nonlinear term that(More)
In this article, we analyze traveling waves in a reaction–diffusion-mechanics (RDM) system. The system consists of a modified FitzHugh–Nagumo equation, also known as the Aliev–Panfilov model, coupled bidirectionally with an elasticity equation for a deformable medium. In one direction, contraction and expansion of the elastic medium decreases and increases,(More)
It is known [8, 11, 16, 26] that phase locking can entrain frequency information when the leaky integrate-and-fire (IF) model of a neuron is forced by a periodic function. We show that this is still the case when the IF model is made more biologically realistic. We incorporate into our model spike dependent threshold modulation and refractory periods.(More)
The purpose of this paper is to explore spatio-temporal pattern formation via invasion fronts in the one and two dimensional Keller-Segel chemotaxis model. In the one-dimensional case, simulations show that solutions that begin near an unstable equilibrium evolve into periodic patterns. These in turn evolve into new patterns through a process known as(More)
Protein A affinity chromatography is a standard technique for the purification of therapeutic antibodies. Recently, multi-column chromatographic processes have emerged to turn classical capture processes into more efficient and continuous systems. The design of such chromatographic processes, be they single-column or multi-column systems, is described in(More)
For singular perturbation problems, the renormalization group (RG) method of Chen, Goldenfeld, and Oono [Phys. has been shown to be an effective general approach for deriving reduced or amplitude equations that govern the long time dynamics of the system. It has been applied to a variety of problems traditionally analyzed using disparate methods, including(More)