Matt Bunting

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1. The role of the central renin-angiotensin system in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR) was examined following acute and chronic intracerebroventricular (i.c.v.) infusions of angiotensin1 (AT1) receptor antagonists. 2. Groups of SHR were chronically instrumented for acute i.c.v. administration of the AT1 receptor(More)
Traffic waves are phenomena that emerge when the vehicular density exceeds a critical threshold. Considering the presence of increasingly automated vehicles in the traffic stream, a number of research activities have focused on the influence of automated vehicles on the bulk traffic flow. In the present article, we demonstrate experimentally that(More)
1. Evidence suggesting an involvement of the brain renin-angiotensin system (RAS) in the development/maintenance of hypertension in spontaneously hypertensive rats (SHR) relies, in part, on early experimental data reporting centrally mediated antihypertensive effects of saralasin. However, recent data using non-peptide AT1 receptor antagonists does not(More)
Since the cardiovascular effects of cholecystokinin (CCK) seem to particularly involve the A ('peripheral') subtype of CCK (CCK[A]) receptor, we examined the actions of two novel, highly selective CCK(A) receptor antagonists, PD140548 (N-alpha-methyl-N[(tricyclo[3.3.1.1(3,7)]dec-2-yloxy)carbony l]-L-tryptophyl]-D-3-(phenylmethyl)-beta-alanine) and SR 27897B(More)
Endothelin has been implicated in the pathogenesis and/or maintenance of hypertension. Endothelin receptor antagonists lower blood pressure in the spontaneously hypertensive rat (SHR), but the regional haemodynamic effects of such drugs in the SHR remain unknown. The aim of this study was to examine the regional haemodynamic effects of the endothelin(More)
Autonomous vehicles and other robotics systems are frequently implemented using a general-purpose programming language such as C++, and prototyped using domain-specific tool such as MATLAB/Simulink, and LabVIEW. Such an approach is not efficient when programming primitive motions of autonomous vehicles when considering important safety constraints, and when(More)
Robotic systems have benefitted from standardized middleware that can componentize the development of new capabilities for a robot. The popularity of these robotic middleware systems has resulted in sizable libraries of components that are now available to roboti- cists. However, many robotic systems (such as autonomous vehicles) must adhere to externally(More)
Managing complexity while ensuring safely designed behaviors is important for cyber-physical systems as they are continually intro- duced to consumers, such as autonomous vehicles. Safety consid- erations are important as programming interfaces become open to experts and non experts of varying degrees. Autonomous vehicles are an example system where many(More)
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