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The hippocampus is deteriorated in various pathologies such as Alzheimer's disease (AD) and such deterioration has been linked to memory impairment. By contrast, the structural and functional effects of normal aging on the hippocampus is a matter of debate, with some findings suggesting deterioration and others providing evidence of preservation. This(More)
OBJECTIVE The objective was to assess the long-term safety profile of dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency (AI). DESIGN Randomised, open-label, crossover trial of DR-HC or thrice-daily hydrocortisone for 3 months each (stage 1) followed by two consecutive, prospective, open-label studies of DR-HC for 6 months (stage(More)
OBJECTIVE It has been suggested that overweight is negatively associated with cognitive functions. The aim of this study was to investigate whether a reduction in body weight by dietary interventions could improve episodic memory performance and alter associated functional brain responses in overweight and obese women. METHODS 20 overweight postmenopausal(More)
Menopause is associated with increased abdominal fat and increased risk of developing diabetes and cardiovascular disease. The present study evaluated the plasma metabolic response in relation to insulin sensitivity after weight loss via diet intervention. This work includes two studies; i) Ten women on a 5 weeks Paleolithic-type diet (PD, 30 energy percent(More)
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