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The progesterone metabolite allopregnanolone, like benzodiazepines, reduces learning and impairs memory in rats. Both substances act as GABA agonists at the GABA-A receptor and impair the performance in the Morris water maze test. Women are during the menstrual cycle, pregnancy, and during hormone replacement therapy exposed to allopregnanolone or(More)
OBJECTIVE To investigate outcomes of cystocele surgery by different anesthesia and evaluation of patient satisfaction. DESIGN Population-based, retrospective study. SETTING All clinics that included patients in the Swedish National Register for Gynecological Surgery. POPULATION A total of 1,364 women who underwent cystocele repair from January 2006 to(More)
BACKGROUND Vaginal hysterectomy is often used to correct uterovaginal prolapse, however, there is little information regarding outcomes after surgery in routine clinical practice. The objective of this study was to investigate complications, sexual activity, urinary symptoms, and satisfaction with health care after vaginal hysterectomy due to prolapse. (More)
AIM Gamma-aminobutyric acid (GABA)-ergic transmission from the hypothalamus is essential for normal feeding regulation, and hyperphagia can be induced by local application of GABAA -receptor agonists to different feeding-associated brain areas. The food intake in rats varies diurnally and that may influence the effect of GABAA -receptor active compounds.(More)
BACKGROUND The role of progesterone levels during human labor is unclear. OBJECTIVE To investigate serum concentrations of progesterone and 5alpha-pregnane-3,20-dione in normal and abnormal deliveries. METHODS Venous and umbilical cord serum samples were collected from 108 parturient women. In a further 49 deliveries, arterial and venous umbilical cord(More)
BACKGROUND In 1996, the Swedish National Register for Gynecological Surgery started to collect pre- and postoperative information on patients using questionnaires given out as part of routine medical care. The information is used in providing clinical care to the patient and for quality assessment. AIMS To evaluate patients' acceptance of questionnaires(More)
AIM The purpose of the study was to evaluate the current use of antibiotic prophylaxis, the rate of postoperative infections, and risk factors for postoperative infections in patients undergoing elective hysterectomy for non-malignant pathology. METHODS The study was performed during the time period July 2000 to 1 January 1 2003, using data from the(More)
BACKGROUND The Board of the Nordic Federation of Societies of Obstetrics and Gynecology established a Quality Group for Gynecological Surgery connected with benign diseases with one member from each of the Nordic countries. The aim was to suggest guidelines for the quality assessment of such surgery. METHODS A questionnaire study was carried out in all(More)
Some women have negative mood symptoms, caused by progestagens in hormonal contraceptives or sequential hormone therapy or by progesterone in the luteal phase of the menstrual cycle, which may be attributed to metabolites acting on the GABA-A receptor. The GABA system is the major inhibitory system in the adult CNS and most positive modulators of the GABA-A(More)
The idea of a virtual sensor is to extract information of parameters that cannot be measured directly, or at least would require very costly sensors, by only using available information. Virtual sensors are described for the friction between road and tire, the tire inflation pressure and wheel imbalance. There are certain in-terconnections between these(More)