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The temporal pharmacokinetic (blood) and neuropharmacokinetic (cerebrospinal fluid, CSF) interrelationship of phenytoin was studied after acute and during chronic (up to 5 days) intraperitoneal administration of phenytoin (30, 50 or 100 mg/kg) using a new freely behaving rat model. After administration, phenytoin rapidly appeared in both serum (Tmax mean(More)
To monitor the spread of human immunodeficiency virus (HIV) in the heterosexual population, residues of blood samples collected routinely on absorbent paper for neonatal screening (Guthrie cards) in NE, NW, and SW Thames Regions in England have been tested for antibodies to HIV-1 since June, 1988. 323,369 dried blood spots were analysed to end March, 1991.(More)
In the past year, ten infants have been admitted to hospital with a new or previously unrecognised disorder, characterised by an acute onset of encephalopathy, fever, shock, watery diarrhoea, severe disseminated intravascular coagulation, and renal and hepatic dysfunction. Seven of the infants died. No specific causative agent has been identified, but(More)
BACKGROUND AND PURPOSE Diffusional kurtosis imaging is an MR imaging technique that provides microstructural information in biologic systems. Its application in clinical studies, however, is hampered by long acquisition and postprocessing times. We evaluated a new and fast (2 minutes 46 seconds) diffusional kurtosis imaging method with regard to glioma(More)
A fully integrated transceiver in a 0.13 mum CMOS technology including on-chip power amplifier (PA) for digital cordless telephone standards is presented. The PA exhibits an output power of P<sub>OUT</sub> = 26 dBm. The implemented frequency synthesizer shows robustness against PA coupling, excellent phase noise performance and fast settling time. The fully(More)
A fully integrated receiver in a 0.13 mum CMOS technology including on-chip power amplifier (PA) for digital cordless telephone standards is presented. The implemented frequency synthesizer shows robustness against PA coupling, excellent phase noise performance and fast settling time. The frequency tuned LNA and IF-filter is designed to cover the frequency(More)