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BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We investigated the efficacy of these two agents combined for first-line treatment of metastatic colorectal cancer. METHODS 387 patients previously untreated with chemotherapy (other than adjuvant) for advanced colorectal cancer were randomly(More)
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the efficacy of this combination in patients with metastatic colorectal cancer. We evaluated the efficacy of treatment with FL plus oxaliplatin in the postoperative adjuvant setting. METHODS We randomly assigned 2246 patients who had(More)
BACKGROUND In phase II trials, irinotecan is active in patients with advanced colorectal cancer, but the survival and clinical benefit of irinotecan compared with second-line fluorouracil by continuous infusion is not known. METHODS 267 patients who had failed to respond to first-line fluorouracil, or whose disease had progressed after treatment with(More)
Ten normal children (mean age = 9 years) and 12 dyslexic children (mean age = 8.1 years) were compared for latency, amplitude and topographic distribution of both parameters of P300. We found a significant increase in P300 latency in the dyslexic group. Noteworthy is the increase in amplitude in the central parietal area in the control group. These facts(More)
Some patients with epithelial-cell cancers develop leptomeningeal carcinomatosis (LC), a severe complication difficult to diagnose and with an adverse prognosis. This study explores the contribution of flow cytometry immunophenotyping (FCI) to the diagnosis and prognosis of LC. Cerebrospinal fluid (CSF) samples from patients diagnosed with LC were studied(More)
Renal disease is a well-recognized complication among patients with HIV infection. Viral infection itself and the use of some antiretroviral drugs contribute to this condition. The thick ascending limb of Henle's loop (TALH) is the tubule segment where free water clearance is generated, determining along with glomerular filtration rate the kidney's ability(More)
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