Matilde Mannucci

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BACKGROUND Open colorectal cancer (CRC) surgery induces severe and prolonged postoperative pain. The optimal method of postoperative analgesia in CRC surgery has not been established. We evaluated the efficacy of preperitoneal continuous wound infusion (CWI) of ropivacaine for postoperative analgesia after open CRC surgery in a multicenter randomized(More)
A multicenter study of a recently developed ELISA for the determination of prothrombin fragment F1+2 was performed in order to evaluate analytical and clinical aspects. Mean intra-assay and inter-assay reproducibility were found to be 11.0 and 12.6%, respectively. The measuring range covered by the calibration curve reaches from 0.04 to 10.0 nM/l F1+2.(More)
Although a number of studies compare different techniques of breast reconstruction, information documenting the factors that affect breast symmetry after unilateral mastectomy and reconstruction seems to be scarce. A statistical analysis of 606 patients undergoing unilateral mastectomy and breast reconstruction performed during a 7 year period was(More)
BACKGROUND Infection is a severe potential complication of breast implant positioning in women with cancer. There still is some degree of uncertainty regarding optimal antibiotic prophylaxis regimens, infecting pathogens, and risk factors associated with infection during long-term followup of these patients. METHODS We performed a systematic clinical(More)
e21157 Background: CTLA-4, a close homologue to CD28, is a vital negative regulator of T-cell activation and proliferation. We previously reported that CTLA-4 is expressed by NSCLC cell lines providing evidence of its involvement in apoptosis induction upon engagement with soluble CTLA-4 ligands (Contardi E, Int J Cancer 2005). The present study examined(More)
Sonoelastography is an imaging technique that provides information on tissue elasticity. Its use as a diagnostic procedure is based on the premise that pathological processes like cancer alter the physical characteristics of the involved tissue. Ultrasonographic studies of the neck can reveal the nonpalpable thyroid nodules, but the nature of these lesions(More)
In one patient with mucopolisaccharidosis endocrine investigation were performed. The results indicate an impaired regulation of hypothalamus-hypophysis-adrenocortical system. The hypothalamus GH sstem appears to be involved to a lesser extent. A dysfunction of the central nervous system is suggested.
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