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- Hiroshi Kondoh, Matilde E L Lleonart, +6 authors David Beach
- Cancer research
- 2005
An unbiased screen for genes that can immortalize mouse embryonic fibroblasts identified the glycolytic enzyme phosphoglycerate mutase (PGM). A 2-fold increase in PGM activity enhances glycolytic… (More)
- Matilde E L Lleonart
- Biochimica et biophysica acta
- 2010
This review focuses on the roles of two major cold-inducible RNA binding proteins known in human cells: CIRP and RBM3. Both proteins were discovered when they were shown to be induced after exposure… (More)
- Venus Sosa, Teresa Moliné, Rosa Somoza, Rosanna Paciucci, Hiroshi Kondoh, Matilde E L Lleonart
- Ageing research reviews
- 2013
Reactive species, which mainly include reactive oxygen species (ROS), are products generated as a consequence of metabolic reactions in the mitochondria of eukaryotic cells. In normal cells,… (More)
- Carlo Mariano Romagosa, Serena Simonetti, +4 authors Santiago Ramón y. Cajal
- Oncogene
- 2011
p16Ink4a is a protein involved in regulation of the cell cycle. Currently, p16Ink4a is considered a tumor suppressor protein because of its physiological role and downregulated expression in a large… (More)
- Hiroshi Kondoh, Matilde E L Lleonart, +5 authors David Beach
- Antioxidants & redox signaling
- 2007
Embryonic stem (ES) cells are immortal and present the ability to self-renew while retaining their ability to differentiate. In contrast, most primary cells possess a limited proliferative potential,… (More)
- Juan Leal, Matilde E L Lleonart
- Cancer letters
- 2013
Cancer stem cells (CSCs) are a sub-population of cancer cells that possess characteristics associated with normal stem cells but with the peculiarity that they are tumourigenic. This property allows… (More)
- Matilde E L Lleonart, Ana Artero-Castro, Hiroshi Kondoh
- Molecular Cancer
- 2008
Cellular immortalization is a crucial step during the development of human cancer. Primary mammalian cells reach replicative exhaustion after several passages in vitro, a process called replicative… (More)
- Maria V. Guijarro, Juan F. M. Leal, +6 authors Amancio Carnero
- Carcinogenesis
- 2007
Tumorigenesis occurs when the mechanisms involved in the control of tissue homeostasis are disrupted and cells stop responding to physiological signals. Therefore, genes capable of desensitizing… (More)
- Ana Artero-Castro, Francisco B Callejas, +6 authors Matilde E L Lleonart
- Molecular and cellular biology
- 2009
Embryonic stem cells are immortalized cells whose proliferation rate is comparable to that of carcinogenic cells. To study the expression of embryonic stem cell genes in primary cells, genetic… (More)
- Viola Borgdorff, Matilde E L Lleonart, +4 authors Daniel Beach
- Oncogene
- 2010
Overexpression of RasG12V in primary cells induces a permanent growth arrest called oncogene-induced senescence (OIS) that serves as a fail-safe mechanism against malignant transformation. We have… (More)