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BACKGROUND Inadequate analgesia during general anaesthesia may present as undesirable haemodynamic responses. No objective measures of the adequacy of analgesia exist. We aimed at developing a simple numerical measure of the level of surgical stress in an anaesthetized patient. METHODS Sixty and 12 female patients were included in the development and(More)
BACKGROUND Direct indicators for the evaluation of the nociceptive-anti-nociceptive balance during general anaesthesia do not exist. The aim of this study was to combine physiological parameters to obtain such an indicator. METHODS Fifty-five females scheduled for surgery under general anaesthesia combining target-controlled infusions of propofol and(More)
Absent response of serum thyrotrophin (TSH) after stimulation with 200 micrograms synthetic thyrotrophin-releasing hormone (TRH) was used as a criterion of adequate suppression of TSH in the treatment of thyroid carcinoma patients with thyroxine. The mean causing total suppression of the response was 223 micrograms of thyroxine per day. At this dose level(More)
BACKGROUND To study adequate antinociception during general anaesthesia, tetanic stimulus of 5-10 s duration has been used previously as a standardized nociceptive stimulus. However, such stimuli have been found to correlate poorly with intraoperative nociception. We hypothesized that an electrical tetanic stimulus of the ulnar nerve, lasting 30 s, would(More)
The second chromosome inversion In (2L+2R) Cy in a heterozygous condition was studied for its effect on frequency and interference of crossing over in three different regions of the X chromosome of Drosophila melanogaster. A significant increase in crossing over frequency was observed in the proximal and distal regioins of the X chromosome while in the(More)
A selective method was developed, based on negative complementation of the Abruptex alleles of the Notch focus, for studying primary sex chromosome non-disjunction in females and males of Drosophila melanogaster and X-Y exchange in males. The results show that the frequency of primary non-disjunction of structurally normal X chromosomes was lower than the(More)
BACKGROUND During maternal cardiac arrest, emergency hysterotomy (EH) is recommended after four minutes of resuscitation, if no signs of spontaneous circulation are detected. This extreme procedure is believed to be potentially beneficial for both the mother and the infant. Both maternal and neonatal survivals seem to be associated to the time delay between(More)
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