Mathieu Hilaire

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Tolcapone is a potent catechol-O-methyltransferase inhibitor that prolongs the plasma half-life of levodopa. This multicenter, double-blind, placebo-controlled study used two 10-hour clinical evaluations to compare the efficacy and safety of three doses of tolcapone (50, 200, and 400 mg tid) with placebo in patients with Parkinson's disease (PD)(More)
Despite widely published speculation regarding a potential potency advantage of short-wavelength (blue-appearing) light for Seasonal Affective Disorder (SAD) treatment, there have been few systematic studies. Those comparing short-wavelength to broad-wavelength (white) light under actual clinical conditions suggest equivalent effectiveness. This(More)
We define and study the following two-player game on a graph G. Let k ∈ N *. A set of k guards is occupying some vertices of G while one spy is standing at some node. At each turn, first the spy may move along at most s edges, where s ∈ N * is his speed. Then, each guard may move along one edge. The spy and the guards may occupy same vertices. The spy has(More)
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