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The expression of Staphylococcus aureus adhesins in Lactococcus lactis identified clumping factor A (ClfA) and fibronectin-binding protein A (FnBPA) as critical for valve colonization in rats with experimental endocarditis. This study further analyzed their role in disease evolution. Infected animals were followed for 3 d. ClfA-positive lactococci(More)
We study the problem of finding solutions to linear equations modulo an unknown divisor p of a known composite integer N. An important application of this problem is factorization of N with given bits of p. It is well-known that this problem is polynomial-time solvable if at most half of the bits of p are unknown and if the unknown bits are located in one(More)
We look at iterated power generators si = s e i−1 mod N for a random seed s0 ∈ ZN that in each iteration output a certain amount of bits. We show that heuristically an output of (1 − 1 e) log N most significant bits per iteration allows for efficient recovery of the whole sequence. This means in particular that the Blum-Blum-Shub generator should be used(More)
Staphylococcus aureus is an important pathogen, causing a wide range of infections including sepsis, wound infections, pneumonia, and catheter-related infections. In several pathogens ClpP proteases were identified by in vivo expression technologies to be important for virulence. Clp proteolytic complexes are responsible for adaptation to multiple stresses(More)
BACKGROUND Pandemic community-acquired methicillin-resistant Staphylococcus aureus isolates (CA-MRSA) predominantly encode the Panton-Valentine leukocidin (PVL), which can be associated with severe infections. Reports from non-indigenous Sub-Saharan African populations revealed a high prevalence of PVL-positive isolates. The objective of our study was to(More)
UNLABELLED Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory lung disease that affects a large number of patients and has significant impact. One hallmark of the disease is the presence of bacteria in the lower airways. OBJECTIVE The aim of this study was to analyze the detailed structure of microbial communities found in the(More)
Multiple sclerosis (MS) is a devastating inflammatory disorder of the central nervous system (CNS). A major hallmark of MS is the infiltration of T cells reactive against myelin components. T cell infiltration is mediated by the interaction of integrins of the beta1 and beta2 family expressed by lymphocytes with their endothelial counter-receptors, vascular(More)