Mathias Dietz

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Systemic lupus erythematosus (SLE) is an autoimmune disorder characterized by production of autoantibodies against intracellular antigens including DNA, ribosomal P, Ro (SS-A), La (SS-B), and the spliceosome. Etiology is suspected to involve genetic and environmental factors. Evidence of genetic involvement includes: associations with HLA-DR3, HLA-DR2,(More)
Several binaural audio signal enhancement algorithms were evaluated with respect to their potential to improve speech intelligibility in noise for users of bilateral cochlear implants (CIs). 50% speech reception thresholds (SRT50) were assessed using an adaptive procedure in three distinct, realistic noise scenarios. All scenarios were highly nonstationary,(More)
For high-frequency complex stimuli, detection thresholds for envelope-based interaural time differences (ITDs) decrease with overall level. Substantial heterogeneity is, however, evident among the findings concerning the rate at which thresholds decline with level. This study investigated factors affecting the influence of overall level on threshold ITDs.(More)
The ability to locate the direction of a target sound in a background of competing sources is critical to the survival of many species and important for human communication. Nevertheless, brain mechanisms that provide for such accurate localization abilities remain poorly understood. In particular, it remains unclear how the auditory brain is able to(More)
In patients with bilateral cochlear implants (CIs), pairing matched interaural electrodes and stimulating them with the same frequency band is expected to facilitate binaural functions such as binaural fusion, localization, and spatial release from masking. Because clinical procedures typically do not include patient-specific interaural electrode pairing,(More)
Psychoacoustic experiments were conducted to investigate the role and interaction of fine-structure and envelope-based interaural temporal disparities. A computational model for the lateralization of binaural stimuli, motivated by recent physiological findings, is suggested and evaluated against the psychoacoustic data. The model is based on the independent(More)
Recently two studies [Klein-Hennig et al., J. Acoust. Soc. Am. 129, 3856-3872 (2011); Laback et al., J. Acoust. Soc. Am. 130, 1515-1529 (2011)] independently investigated the isolated effect of pause duration on sensitivity to interaural time differences (ITD) in the ongoing stimulus envelope. The steepness of the threshold ITD as a function of pause(More)
The auditory system is sensitive to interaural timing disparities in the fine structure and the envelope of sounds, each contributing important cues for lateralization. In this study, psychophysical measurements were conducted with customized envelope waveforms in order to investigate the isolated effect of different segments of a periodic, ongoing envelope(More)
In a collaborative research project, several monaural and binaural noise reduction algorithms have been comprehensively evaluated. In this article, eight selected noise reduction algorithms were assessed using instrumental measures, with a focus on the instrumental evaluation of speech intelligibility. Four distinct, reverberant scenarios were created to(More)