Learn More
Ethoxyresorufin (EROD) and pentoxyresorufin (PROD) O-dealkylase activities, and contributions of the P450 cytochromes CYP1A1, CYP2B1 and 2, CYP2C6 and CYP2C12 to these metabolic activities, were evaluated in hepatic microsomes from ad libitum and calorie restricted female Fischer 344 rats across an age continuum from 1 to 26 months. The presence of CYP1A in(More)
BACKGROUND This study is the first to examine the effect of direct angiotensin II type 2 (AT(2)) receptor stimulation on postinfarct cardiac function with the use of the novel nonpeptide AT(2) receptor agonist compound 21 (C21). METHODS AND RESULTS Myocardial infarction (MI) was induced in Wistar rats by permanent ligation of the left coronary artery.(More)
Amyloid-β peptide deposition, abnormal hyperphosphorylation of tau, as well as inflammation and vascular damage, are associated with the development of Alzheimer's disease (AD). Angiotensin II (Ang II) is a peripheral hormone, as well as a neuropeptide, which binds two major receptors, namely the Ang II type 1 receptor (AT1R) and the type 2 receptor (AT2R).(More)
BACKGROUND In this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R agonists as neuroprotective agents. METHODS AND RESULTS Spontaneously hypertensive rats (SHR) were pre-treated for 5 days prior to stroke with C21 alone or in combination with the AT2R(More)
  • Biosensors Agnesi, F Blaha, +42 authors Siegel
  • 2011
(2010). Local glutamate release in the rat ventral lateral thalamus evoked by high-frequency stimulation. 8). Wireless instantaneous neurotransmitter concentration system–based amperometric detection of dopamine, adenosine, and glutamate for intraoperative neurochemical monitoring. (2009). Toward feedback controlled deep brain stimulation: Dynamics of(More)
  • 1