Mathew W. State

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Congenital heart disease (CHD) is the most frequent birth defect, affecting 0.8% of live births. Many cases occur sporadically and impair reproductive fitness, suggesting a role for de novo mutations. Here we compare the incidence of de novo mutations in 362 severe CHD cases and 264 controls by analysing exome sequencing of parent-offspring trios. CHD cases(More)
Lithium salts have been used extensively in both adults and children during the last 30 years, for the treatment of a variety of psychiatric conditions, including bipolar disorder The cardiac side effects of lithium in adult patients have been well described. However, to the best of our knowledge, there are no reports of lithium-induced cardiac side effects(More)
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