Mathew Hungerford

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Galactosylceramide beta-galactosidase cross reacting material was demonstrated in brain, liver, and skin fibroblasts from patients with Krabbe disease. The mutant enzyme was antigenically identical to the normal enzyme and exhibited similar electrophoretic mobility. Normal quantities of the catalytically deficient enzyme were measured in the patients'(More)
Galactocerebrosidase (beta-d-galactosyl-N-acylsphingosine galactohydrolase; EC 3.2.1.46) activity of brain and liver preparations from normal individuals and patients with Krabbe disease (globoid-cell leukodystrophy) have been separated by gel filtration into four different molecular-weight forms. The apparent mol.wts. were 760000+/-34000 and 121000+/-10000(More)
An important source of evidence concerning rapid adaptation and learning in the brain is the phenomenon of repetition suppression—the longlasting and item-specific decrease in neural responsivity with repeated exposure to an item, yielding a sparser representation. Existing accounts are informal and do little more than describe the phenomenon. In this(More)
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