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Microinjections of glutamate into the dorsal periaqueductal grey (DPAG) of rats induce flight behavior, and blockade of glutamate NMDA receptors in the same region increases exploratory behavior of rats tested on the elevated plus maze. To investigate a possible role of other glutamate receptors in the DPAG on anxiety modulation, rats (n = 6–10) received(More)
To investigate if blockade of the modulatory glycine site of NMDA receptors in the dorsal periaqueductal grey (DPAG) would produce anxiolytic effects, groups of 9–14 rats received microinjections into this structure of 7-chloro-kynurenic acid (7-Cl-KY, 4 and 8 nmol) or 3-amino-1-hydroxypyrrolid-2-one (HA-966, 30 or 100 nmol), two selective antagonists at(More)
The surface/volume ratio and the surface density of the chorionic villi in different cotyledonary regions of the human mature placenta were studied by stereologic methods. The villus surface/volume ratio showed a mean value of 812.3 cm2/cm3 (standard deviation = 89.2 cm2/cm3). There were no significant differences according to the site from which the sample(More)
BACKGROUND Chronic blood transfusion (CBT) is currently the standard of care for primary and secondary stroke prevention in children with sickle cell anemia (SCA). However, the effect of CBT on cerebrovascular pathology is not well known. METHODS We reviewed children with SCA receiving CBT for abnormal transcranial Doppler (TCD) [n=12] or cerebrovascular(More)
The frequency of fibrinoid degeneration in different regions of the human mature placenta was determined employing stereologic methods. The results showed the existence of significantly more frequent fibrinoid degeneration in the venous regions. It is suggested that the hypoxia and/or the relative stasis at these levels could stimulate the fibrinoid(More)
To investigate the behavioral effects of different vehicles microinjected into the dorsal periaqueductal grey (DPAG) of male Wistar rats, weighing 200-250 g, tested in the elevated plus maze, animals were implanted with cannulas aimed at this structure. One week after surgery the animals received microinjections into the DPAG of 0.9% (w/v) saline, 10% (v/v)(More)
The authors studied by means of sterological methods the volume density of syncytial sprouts in different cotyledonary regions of the human term placenta. The syncytial sprouts account for 4.92% of the placenta volume. Meanwhile, there were significant differences according to the site from which the sample was obtained. The lowest value (2.72%) corresponds(More)