Matheus M. dos Santos

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Excessive formation of reactive oxygen species (ROS) and disruption of glutamate uptake have been pointed as two key mechanisms in methylmercury-toxicity. Thus, here we investigate the involvement of glutamatergic system in methylmercury (MeHg) neurotoxicity and whether diphenyl diselenide, ebselen and guanosine could protect cortical rat brain slices from(More)
The aim of the present study was to evaluate the potential pharmacological and toxicological properties of (E)-1-(1-(methylthio)-1-(selenopheny) hept-1-en-2-yl) pyrrolidin-2-one (compound 1), an organoselenium compound. In vitro experiments showed that compound 1 presented a reduction in the lipid peroxidation induced by Fe2+ in thiobarbituric acid-reactive(More)
Diorganoyl dichalcogenide compouds can have antioxidant activity in different in vitro and in vivo models. Here, we have compared the potential antioxidant activity of 1-dinaphthyl diselenide (1-NapSe)2, 2-dinaphthyl diselenide (2-NapSe)2, 1-dinaphthyl distelluride (1-NapTe)2, 2-dinaphthyl ditelluride (2-NapTe)2 with their well-studied analogs diphenyl(More)
Diet is a key component for development and longevity of organisms. Here, the fruit fly was used to evaluate the detrimental effects caused by consumption of high-sucrose diets (HSD), namely phenotypic responses linked to insulin signaling and oxidative stress. The protective effects of extracts from medicinal plants Syzygium cumini and Bauhinia forficata(More)
Proteins play a key role in cells' function and metabolism. Their functions are directly related with the three-dimensional (3D) native structure. Different algorithms have been proposed to predict the 3D protein structure from the amino acids sequence by minimizing its free energy, nonetheless, this problem still a great challenge in structural biology.(More)
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